Creative Biolabs

16,16-Dimethyl Prostaglandin E2 [Prostaglandin E2 Activator; Derivative]

[CAT#: MOD2005ZP63]

Synthetic prostaglandin E2 derivative. Induces stem cell proliferation.

Target:
Prostaglandin E2

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Synonyms
16,16-dimethyl PGE2
Chemical Name
(5Z,11α,13E,15R)-11,15-Dihydroxy-16, 16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid
Modulator Type
Activator; Derivative
Relevant Disease
Neurological Disorders
Assay Description
16,16-Dimethylprostaglandin E2 (10 µg / kg; intraperitoneal; every 12 hours; lasts 8 days) can rescue the deteriorating DSS colitis phenotype of Tpl2IMF-KO mice and restore epithelial proliferation and structure.
Animal Model
Tpl2IMF-KO mice
Dosage
10 µg/kg
Administration
IP; every 12 hours; for 8 days
Result
Rescued the exacerbated DSS colitis phenotype and restores epithelial proliferation and structure.
References
[1]. Roulis M, et al. Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4658-67.
Molecular Weight
380.52
Form
Powder
Chemical Formula
C22H36O5
Source
Synthetic
SMILES
O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C(C)(C)CCCC)[C@H](O)C1
Solubility
Soluble in methyl acetate
CAS NO.
39746-25-3
PubChem Substance ID
5283066
Purity
>98%
Storage
Store at +4°C
Shipping
Room Temperature
Handling Advice
For obtaining a higher solubility, please warm the tube at 37 °C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.
Research Use Only
For research use only
Target
Prostaglandin E2
Official Name
PGE2
Full Name
Prostaglandin E2

For Research Use Only. Not For Clinical Use.
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