A 83-01 [ALK5; ALK4; ALK7 Inhibitor]
Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human induced pluriA highly potent stem cell (hiPSC) self renewal.
Reprogramming: A 83-01 can reprogram fibroblasts into neural stem cells and cardiomyocytes.
Differentiation: A 83-01 blocks SMAD2/3 phosphorylation and inhibits TGF-β-induced epithelial-to-mesenchymal transition
Maintenance/self-renewal: A 83-01 helps to maintain the homogeneity of iPSC and long-term self-renewal in vitro
. Yamamura S, et al. The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer. Int J Cancer. 2012 Jan 1;130(1):20-8.
. Taniguchi Y, et al. Enhanced antitumor efficacy of folate-linked liposomal Adriamycin with TGF-β type I receptor inhibitor. Cancer Sci. 2010 Oct;101(10):2207-13.
According to reports, A 83-01 can be decomposed into A 77-01 in solution. Therefore, we recommend that you form a solution and use it immediately. Don't store solutions.
If the solution needs to be stored, the solution should be dispensed into sealed vials and stored at -20°C for up to one month.