AMI-5 (Eosin Y) [PRMT inhibitor]
[CAT#: NTA-2101-ZP32]
Non-selective PRMT inhibitor. Stain for cytoplasm.
- Biological Activity:
- Non-selective PRMT inhibitors (IC50 values of Hmt1p and PRMT1 are 0.8 and 1.4μM, respectively). Cytoplasmic staining. Disable DOT1 and SET7. Reduce the methylation of H3 histone at lysine 4.
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Synonyms
Non-selective PRMT inhibitor. Stain for cytoplasm.
Chemical Name
2-(2,4,5,7-Tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate disodium salt
Biological Activity
Non-selective PRMT inhibitors (IC50 values of Hmt1p and PRMT1 are 0.8 and 1.4μM, respectively). Cytoplasmic staining. Disable DOT1 and SET7. Reduce the methylation of H3 histone at lysine 4.
Modulator Type
Inhibitor
Applications
Ion Indicator
Molecular Weight
691.85
Form
Form / State: Solid
Chemical Formula
C20H6Br4Na2O5
Source
Synthetic
SMILES
C1=CC=C(C(=C1)C2=C3C=C(C(=O)C(=C3OC4=C(C(=C(C=C24)Br)[O-])Br)Br)Br)C(=O)[O-].[Na+].[Na+]
Solubility
Soluble in water to 3 mM and in ethanol
CAS NO.
CAS Number: 17372-87-1
PubChem Substance ID
11048
Purity
Purity:> 90%
Storage
Store at +4°C. The product can be stored for up to 12 months.
Handling Advice
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
For Research Use Only. Not For Clinical Use.
