Product
Anti-ADAM10 Monoclonal Antibody (CBP3966)
[CAT#: NAB2012899LS]
Anti-ADAM10 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human; African green monkey; Baboon; Cynomolgus; Rhesus
- Applications:
- FC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
CD156c, also known as integrin and metalloprotease domain-containing protein 10 (ADAM10), is a 748 amino acid type I membrane glycoprotein that is commonly expressed on most cell types. It is composed of multiple functional domains, including N-terminal prodomain, catalytic domain, cysteine-rich domain, transmembrane domain and cytoplasmic domain. It is secreted as a precursor protein and becomes the activated/mature form by removing the ADAM10 prodomain by proprotein convertase 7 and furin. ADAM10 is used as a metalloprotease and can cleave multiple molecules, including Notch, TNF-α precursor, amyloid precursor protein, myelin basic protein and type IV collagen. It mediates the release of several cell adhesion molecules, such as vascular endothelial cadherin or L-selectin, to regulate endothelial permeability and leukocyte migration. The imbalance of ADAM activity may contribute to the pathogenesis of vascular diseases.
Species Reactivity
Human; African green monkey; Baboon; Cynomolgus; Rhesus
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1, κ
Clone Number
CBP3966
Applications
FC
Application Notes
FCM (5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
ADAM10
Official Name
ADAM10
Full Name
ADAM metallopeptidase domain 10
Alternative Names
A disintegrin and metalloprotease domain 10;
A disintegrin and metalloproteinase domain 10;
AD 10;
AD10;
AD18;
ADA10_HUMAN;
ADAM 10;
ADAM metallopeptidase domain 10;
ADAM10;
CD 156c;
CD156c;
CD156c antigen;
A disintegrin and metalloproteinase domain 10;
AD 10;
AD10;
AD18;
ADA10_HUMAN;
ADAM 10;
ADAM metallopeptidase domain 10;
ADAM10;
CD 156c;
CD156c;
CD156c antigen;
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
