Product
Anti-Ubiquilin-2 Monoclonal Antibody (CBP3738)
[CAT#: NAB2012102LS]
Anti-Ubiquilin-2 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human; Rat
- Applications:
- WB; IHC-P
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Ubiqulin-2 is a ubiquitin-like protein that facilitates the degradation of ubiquitinated proteins by mediating their binding to the proteasome. Mutations in ubiquilin-2 have been linked to neurodegenerative diseases such as amyotrophic lateral sclerosis and frontal temporal dementia. These mutations are linked to disruption and impairment in the delivery of ubiquitinated substrates to the proteasome. In addition, ubiquilin-2 can interact with components of the ERAD machinery and localizes to autophagosomes, indicating that it plays a role in these pathways.
Immunogen
Human Ubqln2 recombinant protein
Species Reactivity
Human; Rat
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2b, κ
Clone Number
CBP3738
Applications
WB; IHC-P
Application Notes
WB (1.0-10 µg/mL); IHC (2.0-5.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
