Creative Biolabs

AR-A 014418 [GSK3 Inhibitor]

[CAT#: MOD2005ZP490]

A highly potent, selective GSK3 inhibitor

Target:
GSK-3

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Description
A highly effective and selective GSK3 inhibitor (IC50 = 104 nM) with competitive effects. cdk2 and cdk5 are almost inactive (IC50 value> 100 µM). It also inhibits tau phosphorylation (IC50 = 2.7 µM).
Chemical Name
N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
Modulator Type
Inhibitor
Relevant Disease
Neurological Disorders
Molecular Weight
688.83
Chemical Formula
C12H12N4O4S
SMILES
O=C(NCC2=CC=C(OC)C=C2)NC1=NC=C([N+]([O-])=O)S1
Solubility
Soluble in DMSO (100mM) or ethanol (5mM)
CAS NO.
487021-52-3
PubChem Substance ID
448014
Purity
>99%
Storage
+4°C
Shipping
Room Temperature
Research Use Only
For research use only
Target
GSK-3
Official Name
GSK-3
Full Name
Glycogen synthase kinase 3
Alternative Names
Glycogen Synthase Kinase 3; GSK3; Glycogen Synthase Kinase-3
Gene ID
2932(Human); 56637(Mouse); 84027(Rat)
Uniprot ID
P49841(Human); Q9WV60(Mouse); P18266(Rat)
For Research Use Only. Not For Clinical Use.
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