Creative Biolabs

(±)-Bay K 8644 [L-type Ca2+ channel; Calcium channel Agonist]

[CAT#: MOD2005ZP71]

L-type Ca2+ channel agonist. Aids iPSCs generation from Mouse embryonic fibroblasts.

Target:
L Glutamate

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Description
L-type Ca2+ channel agonist. Causes decreased muscle strength of the heart muscle. It also helps to induce mouse embryonic fibroblasts (MEF) to produce pluripotent stem cells. Exhibits convulsions and vasoconstriction.
Chemical Name
1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
Modulator Type
Agonist
Relevant Disease
Neurological Disorders
Assay Description
The conventional racemic mixture of Bay K 8644 is widely used as an L-type Ca2+ channel agonist. Each optical isomer has the opposite effect on IBa, with (R)-(+)-Bay-K-8644 as an antagonist, and S(-)-Bay K 8644 as an agonist. (R)-(+)-Bay-K-8644 suppresses Ba2+ current (IBa) (IC50 = 975 nM). When (R)-(+)-Bay-K-8644 (0.5 μM) was applied, IBa was suppressed to 71±10% of the control. (R)-(+)-Bay-K-8644IBa [1] exists. (R)-(+)-Bay-K-8644 is a calcium channel inhibitor [2].
Reference
[1]. Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15.

[2]. Sidaway P, et al. L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle. PLoS One. 2014 Apr 3;9(4):e93803.
Molecular Weight
356.3
Form
Powder
Chemical Formula
C16H15F3N2O4
Source
Synthetic
SMILES
COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1C(F)(F)F)[N+]([O-])=O
Solubility
Soluble in ethanol (100mM)
IC50
975 nM (IBa)
CAS NO.
71145-03-4
PubChem Substance ID
2303
Purity
>99%
Storage
Store at +4°C
Shipping
Room Temperature
Handling Advice
For obtaining a higher solubility, please warm the tube at 37 °C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -25°C for several months.
Research Use Only
For research use only
Target
L Glutamate
Official Name
L Glutamate
Full Name
L Glutamate

For Research Use Only. Not For Clinical Use.
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