Creative Biolabs

BDNF Protein, Human

[CAT#: NPP-2011-ZP409]

Species:
Human

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Description
BDNF, also known as brain-derived neurotrophic factor and abrineurin, is a neurotrophin belonging to the NGF-beta family. It is expressed highly in the brain, and moderately in the heart, lung, skeletal muscle and placenta. BDNF signals through its high affinity receptor gp145/trkB to exert neurotrophic properties. It has been shown to be involved in the survival and differentiation of both the central and peripheral nervous system. Specifically, BDNF regulates synaptic transmission, axonal growth and path-finding, as well as dendritic growth and morphology.
Species
Human
Biological Activity
ED50<4μg/ml, measured in a bioassay using C6 cells.
Expression Host
CHO
Amino Acids
HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLEKVPVSKGQLK QYFYETKCNP MGYTKEGCRG IDKRHWNSQCRTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR
Molecule Mass
12-14kDa, observed by reducing SDS-PAGE.
Formulation
Lyophilized after extensive dialysis against PBS.
Purity
> 95% as analyzed by SDS-PAGE.
Endotoxin Level
<0.2 EU/μg, determined by LAL method.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Lyophilized recombinant human BDNF remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human BDNF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Handling Advice
Reconstituted in ddH2O or PBS at 100 μg/ml.
Research Use Only
This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Target
BDNF
Official Name
Brain Derived Neurotrophic Factor
Full Name
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]
Alternative Names
Secreted
Gene ID
P23560 (Human); P21237 (Mouse); P23363 (Rat)
Uniprot ID
Neural Antibodies
Neural Proteins & Peptides
Kits
Biomaterials
For Research Use Only. Not For Clinical Use.
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