Creative Biolabs

Behavioral Testing Services

Behavioral Testing Services

Animal models are extremely useful tools in defining the pathogenesis and treatment of human disease. From the simplest measurement of certain symptoms to complex neuropsychological tasks, it is essential to fully understand the nature of behavioral assessment. Creative Biolabs is an innovative, experienced provider of products and solutions for the neuroscience research field. We provide a wide range of behavioral test services for various indications.

For Behavioral Research, Rats or Mice?

The rat and mouse belong to the family Muridae. Although these two species of rodents share similarities, they are different in genetics, physiology, and behavior. Rats have been the most used mammal model for the study of pain. The use of mice in biomedical research has gained great popularity owing to the development of transgenic mouse technology. Choosing which species to work on depends on the question you want to answer as well as the experimental paradigm. Both species have their advantages and disadvantages and have proved to be reliable and indispensable subjects for biomedical research.

A selection of behavioral tests for mice.Fig.1 A selection of behavioral tests for mice. (Brooks, 2009)

Testing Conditions

To obtain reliable, repeatable, and valuable data, test procedures must follow several rules established before the beginning of a study or preliminary experiment. Once identified, it should not be changed throughout the study.

  • Environment

Behavioral testing should be conducted in a quiet, warm, airy, minimally intrusive room with adequate light and possible darkness.

  • Animals

In any given study, only one strain should be used if differences between the different strains are not the subject of the study. The animals should be of the same age or the same weight.

  • The housing of the animals

Scientists prefer to house the animals in cages of two because separation might increase the stress of the rat. The substrate in the animal's cage should be soft, smooth, and absorbent to avoid skin, joint, and bone complications.

  • Animal behavior during testing

The behavior of the animals during the test is divided into (i) spontaneous behaviors, (ii) triggered behaviors, and (iii) trained behaviors.

  • Video-monitoring
  • Pre-training
  • Lab diet, motivators, and attractants
  • Pharmacological treatment
  • Time factors

Behavioral Tests of Diseases at Creative Biolabs

Behavioral and psychological symptoms of Alzheimer's disease (AD) are common during disease evolution. Neuropsychological tests can screen for cognitive, behavioral, and functional changes and assist physicians in the diagnostic process and planning of disease treatment and management strategies.

Parkinson's disease (PD) is a neurodegenerative disorder traditionally classified as a movement disorder. The selection of an appropriate behavioral test is very important. An appropriate test can provide strong evidence for the evaluation of the severity of patients and/or the efficacy of a certain new therapy.

Advantages of Behavioral Test

There are advantages to using behavioral tests. First, evaluating multiple behavioral responses in the same mouse allows one to determine if there are correlative phenotypes across several domains of central nervous system (CNS) function. Second, evaluating the same mouse on multiple behavioral assays reduces the total number of mice needed to complete a project. Third, assessment of a mutant animal on multiple behavioral paradigms that involve overlapping CNS circuitry will give not only more confidence in any observable phenotypic differences but will alsoa more accurately demonstrate the broad range of the phenotype.

At Creative Biolabs, we challenge ourselves to think out of the box and innovate. Our team of experts is engrossed in providing the best quality, customizable service you deserve. If you are interested in our behavioral test services, please feel free to contact us for more.

Reference

  1. Brooks, S.P.; Dunnett, S, B. Tests to assess motor phenotype in mice: a user's guide. Nature Reviews Neuroscience. 2009, 10(7): 519-529.
For Research Use Only. Not For Clinical Use.
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