Creative Biolabs

BIO [GSK-3α/β Inhibitor]

[CAT#: MOD2005ZP72]

A highly potent GSK-3α/β inhibitor. Maintains ESC self-renewal and pluripotency.

Target:
GSK3 Alpha GSK3 Beta

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Description
Powerful GSK-3α/β inhibitor (IC50 = 5 nM). It showed that the activities of CDK1/cyclin B, CDK2/cyclinA, CDK4/cyclin D1, CDK5/p35, MAPKK and PKC subunit α were decreased (IC50 values were 0.32, 0.30, 10, 0.08, 10 and 12μM, respectively). Induces β-catenin to stabilize and protect hippocampal neurons from damage by Aβ oligomers. It also inhibits Tyr276/216 phosphorylation and reduces β-catenin phosphorylation. Cells are permeable. Maintain the self-renewal and pluripotency of embryonic stem cells, and show the characteristics of enhancing proliferation.
Synonyms
6-BIO; 6BIO
Chemical Name
(2'Z,3'E)-6-Bromoindirubin-3'-oxime
Modulator Type
Inhibitor
Relevant Disease
Neurological Disorders
Molecular Weight
356.17
Form
Powder
Chemical Formula
C16H10BrN3O2
Source
Synthetic
SMILES
O/N=C(C1=CC=CC=C1N2)/C2=C3/C(NC4=C3C=CC(Br)=C4)=O
Solubility
Soluble in DMSO (10mM) or ethanol (10mM)
CAS NO.
667463-62-9
PubChem Substance ID
448949
Purity
>98%
Shipping
Room Temperature
Handling Advice
For obtaining a higher solubility, please warm the tube at 37 °C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -26°C for several months.
Research Use Only
For research use only
Target
GSK3 Alpha GSK3 Beta
Official Name
GSK3 alpha; GSK3 beta
Alternative Names
Glycogen synthase kinase 3 is a serine/threonine protein kinase that mediates the addition of phosphate molecules to serine and threonine amino acid residues. Glycogen synthase was first discovered in 1980 as its regulatory kinase of the same name. Since then, GSK-3 has been identified as a kinase for more than 100 different proteins through various pathways. In mammals, GSK-3 is encoded by two paragenes GSK-3 alpha (GSK3A) and GSK-3 beta (GSK3B). GSK-3 has recently been involved in many diseases because it is associated with many diseases, including type 2 diabetes (type 2 diabetes), Alzheimer's disease, inflammation, cancer and bipolar disorder.

For Research Use Only. Not For Clinical Use.
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