BIX 01294 [G9a/GLP HMTases Inhibitor]
A highly potent, selective GLP / G9a HMTase inhibitor. A highly potentiates iPSC induction.
BIX-01294 (5 µM) reduces the level of overall H3K9 methylation in prokaryotic and 2-cell embryos. Embryos temporarily exposed to BIX-01294 have a reduced ability to establish pregnancy .
BIX-01294 (1 µg/mL) resulted in reduced BrdU incorporation of fetal PASMC. BIX-01294 treatment can reduce the migration of PASMCs induced by PDGF .
. Park KE, et al. IVMBIX-01294, an inhibitor of the histone methyltransferase EHMT2, disrupts histone H3 lysine 9 (H3K9) dimethylation in the cleavage-stage porcine embryo. Reprod Fertil Dev. 2012;24(6):813-21.
. Yang Q, et al. BIX-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cells. Cell Prolif. 2012 Aug;45(4):335-44.