
BIX 01294 [G9a/GLP HMTases Inhibitor]
[CAT#: MOD2005ZP73]
A highly potent, selective GLP / G9a HMTase inhibitor. A highly potentiates iPSC induction.
- Target:
- G9a / GLP HMTases
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
BIX-01294 (5 µM) reduces the level of overall H3K9 methylation in prokaryotic and 2-cell embryos. Embryos temporarily exposed to BIX-01294 have a reduced ability to establish pregnancy [2].
BIX-01294 (1 µg/mL) resulted in reduced BrdU incorporation of fetal PASMC. BIX-01294 treatment can reduce the migration of PASMCs induced by PDGF [3].
[2]. Park KE, et al. IVMBIX-01294, an inhibitor of the histone methyltransferase EHMT2, disrupts histone H3 lysine 9 (H3K9) dimethylation in the cleavage-stage porcine embryo. Reprod Fertil Dev. 2012;24(6):813-21.
[3]. Yang Q, et al. BIX-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cells. Cell Prolif. 2012 Aug;45(4):335-44.