Creative Biolabs

BVT 948 [PTP Inhibitor]

[CAT#: MOD2005ZP622]

Non-competitive irreversible PTP inhibitor

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Description
Non-competitive, irreversible protein tyrosine phosphatase (PTP) inhibitor (Ki = 1.2 µM for PTP-1B). Inhibits multiple PTPs (PTP-1B, TCPTP, SHP-2, LAR, and YopH have IC50 values ​​of 0.9, 1.7, 0.09, 1.5, and 0.7 µM, respectively). Inhibits several cytochrome P450 subtypes and inhibits MMP-9, and prevents TPA-induced NF-κB activation. No activity on MAPK. Enhance insulin sensitivity. Shows the ability to cross cell membranes.
Modulator Type
Inhibitor
Relevant Disease
Neurological Disorders
Molecular Weight
621.77
Chemical Formula
C14H11NO3
SMILES
CC1(C2=C(C3=CC=CC=C3C(=O)C2=O)NC1=O)C
Solubility
Soluble in ethanol or DMSO (50mM)
CAS NO.
39674-97-0
PubChem Substance ID
6604934
Storage
Room temperature
Shipping
Room Temperature
Research Use Only
For research use only
For Research Use Only. Not For Clinical Use.
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