AAV Control Tools
AAV control tools can be used both to identify cells and as a negative control. Control AAV is a commonly utilized tool in gene therapy research. It is a vector comparable to therapeutic AAV but lacks the therapeutic gene. Researchers can use control AAV to evaluate treatment effects, discover therapy mechanisms, and verify treatment specificity and effectiveness. AAV serotype, promoter, and reporter gene are three main factors to consider when choosing a control AAV. Ideally, you would use a control with the same serotype and promoter as the AAV expressing your GOI/shRNA/sgRNA.
Applications
| Applications | Description |
| Evaluate treatment effectiveness | Control AAV is frequently employed as a control group to evaluate the effects of therapeutic AAV interventions. By comparing the performance of the treatment group to the control group, the efficacy of the treatment and potential confounding factors can be determined. |
| Determine the mechanism of treatment | Control AAV assists researchers in determining the mechanism of action of a treatment. The biological impacts of treatment and control groups can be compared to gain a better understanding of the therapeutic intervention's pathways and mechanisms. |
| Verify treatment specificity | The treatment's specificity is further validated by the introduction of a control AAV. By ensuring that the control group does not contain the therapeutic gene, one can be certain that the treatment effect is caused by the therapeutic AAV and not by some other factor. |
| Test the effectiveness of treatment | Treatment efficacy can also be evaluated with control AAVs. It is possible to ascertain whether a treatment can appreciably improve the biological effect or disease state by contrasting the outcomes of the treatment group with those of the control group. |
| Develop animal disease models | Control AAV is also used in the development of animal models for disease research to confirm the specificity and efficacy of disease models and treatments. |
Control AAV is an essential tool in gene therapy research. With the ongoing advancement of gene therapy, the use of control AAV will continue to provide vital support for gene therapy research while also promoting the optimization of treatment techniques.
Creative Biolabs offers a range of ready-to-use control AAVs, please browse our product list to find what you need. You can also freely mix serotypes, promoters, functional genes, and expression methods according to your experimental needs, and we are happy to provide you with customized products. Kindly get in touch with us to expedite your research on gene therapy.
For Research Use Only. Not For Clinical Use.
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AAV-pEF1a-EBFP-TA(n)-WPRE-HGH polyA [CAT#: NRZP-0822-ZP247]
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AAV-pEF1a-DIO-ITA(C)-WPRE-hGH polyA [CAT#: NRZP-0822-ZP246]
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AAV-pEF1a-DIO-EBFP-ITA(n)-WPRE-HGH polyA [CAT#: NRZP-0822-ZP245]
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BrainBow™ rAAV-EF1a-BbChT-WPRE-hGH polyA [CAT#: NRZP-0822-ZP212]
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pShuttle-SYN-eGFP [CAT#: NRZP-0622-ZP814]
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pMMP-f2-IRES-EGFP [CAT#: NRZP-0622-ZP811]
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Lenti-CBA-ZsGreen [CAT#: NRZP-0622-ZP797]
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