Alpha Synuclein Antibodies

Alpha Synuclein (SNCA, α-Synuclein) is a soluble protein expressed in the presynaptic and perinuclear regions of the central nervous system (CNS). SNCA is one of the earliest genes associated with Parkinson's disease (PD). SNCA is closely linked to the pathogenesis and associated dysfunction of PD and is the major component of Lewy bodies. At the same time, studies have shown that SNCA is involved in the pathological process of Alzheimer's disease (AD). More than 50% of AD patients have been found to have SNCA tangles in their brains, and patients with SNCA tangles tend to show faster cognitive decline than pure AD patients.

α-Synuclein Pathogenic Mechanism

One of the pathological changes in PD is the deposition of Lewy bodies, and misfolded α-Syn is the major component of Lewy bodies. α-Syn has multiple conformational structures. Under physiological conditions, monomeric α-syn is naturally unfolded with a complete N-terminal domain, central NAC domain, and C-terminal domain that binds to cell membrane phospholipids to complete its physiological functions.

Experimental results show that oligomeric α-syn is the truly neurotoxic α-syn, and it has been demonstrated that oligomeric α-syn is an important form of α-syn fibrils. Studies have shown that oligomeric α-syn exerts neurotoxic effects mainly in the following ways:

• Mitochondrial dysfunction
• Endoplasmic reticulum dysfunction
• Protease activity
• Glial cell inflammatory response
• Cell membrane damage
• Lysosomal dysfunction
• Synaptic dysfunction

α-Synuclein Antibodies Selection Guide

Creative Biolabs stands for high quality antibody products. Our α-Synuclein antibodies are specifically validated to bind to the stated antigen, helping to accelerate your α-Synuclein-related in vivo and in vitro experiments. If you can't find the antibody you need, contact us now to develop custom antibodies for specific targets, species, and applications. Our scientific customer service is always there for you.

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