Alpha Synuclein Antibodies
Alpha Synuclein (SNCA, α-Synuclein) is a soluble protein expressed in the presynaptic and perinuclear regions of the central nervous system (CNS). SNCA is one of the earliest genes associated with Parkinson's disease (PD). SNCA is closely linked to the pathogenesis and associated dysfunction of PD and is the major component of Lewy bodies. At the same time, studies have shown that SNCA is involved in the pathological process of Alzheimer's disease (AD). More than 50% of AD patients have been found to have SNCA tangles in their brains, and patients with SNCA tangles tend to show faster cognitive decline than pure AD patients.
α-Synuclein Pathogenic Mechanism
One of the pathological changes in PD is the deposition of Lewy bodies, and misfolded α-Syn is the major component of Lewy bodies. α-Syn has multiple conformational structures. Under physiological conditions, monomeric α-syn is naturally unfolded with a complete N-terminal domain, central NAC domain, and C-terminal domain that binds to cell membrane phospholipids to complete its physiological functions.
Experimental results show that oligomeric α-syn is the truly neurotoxic α-syn, and it has been demonstrated that oligomeric α-syn is an important form of α-syn fibrils. Studies have shown that oligomeric α-syn exerts neurotoxic effects mainly in the following ways:
- Mitochondrial dysfunction
- Endoplasmic reticulum dysfunction
- Protease activity
- Glial cell inflammatory response
- Cell membrane damage
- Lysosomal dysfunction
- Synaptic dysfunction
α-Synuclein Antibodies Selection Guide
Creative Biolabs stands for high quality antibody products. Our α-Synuclein antibodies are specifically validated to bind to the stated antigen, helping to accelerate your α-Synuclein-related in vivo and in vitro experiments. If you can't find the antibody you need, contact us now to develop custom antibodies for specific targets, species, and applications. Our scientific customer service is always there for you.
Target | Cat. No | Product Name | Host | Application |
Alpha Synuclein pSer129 | NAB2007FY547 | Rabbit Anti-Alpha Synuclein pSer129 Monoclonal Antibody (CBP1974) | Rabbit | ELISA; WB; ICC; IF; IHC |
NAB-0720-Z5605 | Mouse Anti-Alpha-synuclein (CBP3095) | Mouse | IHC-P; IHC-Fr | |
NAB2012436LS | Mouse Anti-Human α-Synuclein Phospho (CBP3878) | Mouse | IHC-P; ICC; IHC-F; WB | |
NAB-08-PZ079 | Rabbit Anti-Alpha-synuclein (CBP1631) | Rabbit | WB; DB; ELISA; IHC-P | |
Alpha Synuclein phospho Y125 | NAB-08-PZ082 | Rabbit Anti-Human Alpha-synuclein (CBP1633) | Rabbit | ICC; WB |
NAB-0720-Z5611 | Rabbit Anti-Alpha-synuclein (CBP3099) | Rabbit | WB; ICC | |
SNCB/SNCA | NAB-0720-Z5596 | Rabbit Anti-SNCB/SNCA Monoclonal Antibody (CBP3090) | Rabbit | FC; WB; ICC; IF |
All Alpha Synuclein Isoforms | NRZP-1022-ZP4121 | Anti-Alpha Synuclein Antibody, NRZP-1022-ZP4121 | Humanized | In Vitro |
NRZP-1022-ZP4122 | Anti-Alpha Synuclein Antibody, NRZP-1022-ZP4122 | Humanized | In Vitro | |
NRZP-1022-ZP4123 | Anti-Alpha Synuclein Antibody, NRZP-1022-ZP4123 | Humanized | In Vitro | |
NRZP-1022-ZP4124 | Anti-Alpha Synuclein Antibody, NRZP-1022-ZP4124 | Humanized | In Vitro | |
NRZP-1022-ZP4125 | Anti-Alpha Synuclein Antibody, NRZP-1022-ZP4125 | Humanized | In Vitro |
See all α-Synuclein antibodies
- iNeuMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- iNeuMab™ Anti-F-Spondin/SPON1 Antibody, Clone 3F4 (Cat#: NRZP-0822-ZP4740)
- iNeuMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- iNeuMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- Mouse Glioma Cell Line GL261 (Cat#: NCL-2108P28)
- Human Retinal Epithelial Cell ARPE-19 (Cat#: NCL2110P069)
- Mouse Midbrain Dopaminergic Neuron Cell MN9D (Cat#: NCL2110P059)
- Immortalized Human Cerebral Microvascular Endothelial Cells (Cat#: NCL-2108-P020)
- iNeu™ Human Motor Neurons (Cat#: NCL-2103-P71)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- Green Fluorescent Tau cell Line (Cat#: NCL2110P219)
- Human Brain Microvascular Endothelial Cells (Cat#: NCL-2103-P133)
- Mouse Microglia N9 (Cat#: NCL2110P073)
- Rat Microglia Cell Line HAPI, Immortalized (Cat#: NCL2110P015)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)