Alzheimer's Disease Related Research Tools
Alzheimer's disease (AD) is the most common form of dementia, a complex neurodegenerative brain disorder characterized by the progressive impairment of cognitive functions, particularly memory, thinking, language, mood, and behavioral issues.
AD is biologically defined by the presence of β-amyloid (Abeta) -containing plaques and tau-containing neurofibrillary tangles. Abeta plaques are formed by the aggregation of beta-amyloid peptides, which are fragments of a larger protein called amyloid precursor protein (APP).
Tau tangles, on the other hand, result from the abnormal phosphorylation and aggregation of tau protein, which is normally involved in maintaining the stability of microtubules within neurons. In Alzheimer's disease, tau protein forms twisted filaments called neurofibrillary tangles.
The accumulation of beta-amyloid plaques and tau tangles initiates a cascade of events that contribute to the progressive neurodegeneration observed in AD. This includes the activation of immune cells (microglia), inflammation, impairment of synaptic connections, and disruption of various signaling pathways in the brain.
As the disease progresses, affected individuals experience a decline in cognitive abilities, memory loss, disorientation, language difficulties, and changes in behavior and personality.
Biological Processes and Targets Related to Alzheimer's Disease
| Biological processes | Targets |
| Amyloid-beta plaques formation | APP, Aβ, PSEN1, PSEN2, B2M, Gal-3, AICD, BACE1, RAGE, ADAM, ApoE4, NEP, IDE, GSK-3 |
| Neurofibrillary tangle formation | Tau, NF-kB, TNF-α, ILs, Cdc42, GSK-3β, CDK5, TPK-1, MARK, MAPK, AMPK, Dyrk1A, p53, PAC1R, ERK, CREB, CaMKII |
| Neuroinflammation | TNF-α, TREM2, CD33, NF-κB, CD36, Calhm2, NLRP2, APOE, PGE2, IL-1, IL-2, IL-4, IL-1β, IL-6, IL-10, IFN-γ, TGF-β, SR-A, CR1, ABCA7, KMO, IFN-γ, P2X7R, TLR, CSF1R, miR-155, STAT3, CaSR, ABCA1, BACE1, Aqp4 |
| Oxidative stress | NRF2, NADPH, PGC1α, miRNA-485, SIRT-1, PPAR-α |
| Mitochondrial dysfunction | PGC1α |
| Cholinergic insufficiency | AChE, BuChE, NGF |
| Autophagy dysfunction | PKA, Drp-1, Parkin, mTOR, AMPK, LOX |
| Neurovascular dysfunction | GLUT1, LRP1, P-gp, RAGE, CypA-MMP9 |
| Synapse loss and alterations | NLRP3, RhoA, BDNF, PKCɛ, Jacob, NCAM, MAPK, ERK, NGF, ACSS2, CREB, NMDAR |
| Ferroptosis | NRF2, GPX4, GSS |
| Lipid dyshomeostasis | APOE, HMG-CoA, ACAT1 |
| Genetic risk factor | APOE4, APP, PSEN1, PSEN2 |
Creative Biolabs offers a wide range of cutting-edge research products geared toward the investigation of biological processes underlying Alzheimer's disease. Our products including antibodies, cell lines, proteins & peptides, and assay kits, are among the bio-reagents keenly sought by neuroscience researchers.
Target
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Mouse monoclonal to GAPDH
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; WB
- Conjugation:
- Unconjugated
Mouse monoclonal to GAPDH
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- IF; WB
- Conjugation:
- Unconjugated
Anti-GAPGH Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- DB; ELISA; WB
- Conjugation:
- Unconjugated
Anti-GAPGH Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat; Cat; Cow; Goat; Porcine
- Applications:
- ELISA; IF; WB
- Conjugation:
- Unconjugated
Anti-GAPGH Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human; Cat; Dog; Porcine; Rabbit
- Applications:
- ELISA; IF; WB
- Conjugation:
- Unconjugated
Anti-GAPGH Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; WB; IF
- Conjugation:
- Unconjugated
Anti-GAPGH Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
- Conjugation:
- Unconjugated
Ascites
Anti-GAPGH Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; IHC; IF; WB
- Conjugation:
- Unconjugated
Anti-GAPGH Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; IHC
- Conjugation:
- Unconjugated
Mouse Monoclonal Antibody to GAPDH
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Rat; Rabbit; Chicken; Cow; Dog; Human; Xenopus laevis; Chinese hamster
- Applications:
- WB
- Conjugation:
- HRP
Rabbit Monoclonal Antibody to GAPDH
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Chicken; Human; Fish; Monkey; Zebrafish; Xenopus tropicalis
- Applications:
- IP; FC; ICC; IF; IHC-P; WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
Rabbit Monoclonal Antibody to GAPDH
- Host Species:
- Rabbit
- Species Reactivity:
- Mouse; Rat; Rabbit; Goat; Cow; Cat; Dog; Human; Porcine; Fish
- Applications:
- IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
Mouse Monoclonal Antibody to GAPDH
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ICC; IF; WB; FC; IP; In-Cell ELISA
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
Mouse Monoclonal Antibody to GAPDH
- Host Species:
- Mouse
- Species Reactivity:
- Mouse; Human
- Applications:
- WB; IHC-P
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC
- iNeuMab™ Anti-Amyloid Beta 1-15 Antibody (NRP-0422-P867) (Cat#: NRP-0422-P867)
- iNeuMab™ Anti-SEZ6 Antibody (NRP-0422-P517) (Cat#: NRP-0422-P517)
- iNeuMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P2275) (Cat#: NRP-0422-P2275)
- iNeuMab™ Anti-TREM2 BBB Shuttle Antibody (NRZP-1022-ZP4114) (Cat#: NRZP-1022-ZP4114)
- iNeuMab™ Anti-Integrin αvβ8 BBB Shuttle Antibody (NRZP-1222-ZP1218) (Cat#: NRZP-1222-ZP1218)
- iNeuMab™ Anti-TREM2 Antibody (NRP-0422-P792) (Cat#: NRP-0422-P792)
- iNeuMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- iNeuMab™ Anti-pTau Antibody (NRP-0422-P1719) (Cat#: NRP-0422-P1719)
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P1760) (Cat#: NRP-0422-P1760)
- Mouse Retinal Ganglion Cell Line RGC-5 (Cat#: NCL2110P154)
- Human Brain Vascular Adventitial Fibroblasts (Cat#: NCL-21P6-014)
- Human Brain Astroblastoma U-87 MG (Cat#: NCL2110P117)
- Mouse Microglia Cell Line BV-2, Immortalized (Cat#: NCL2110P153)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- Mouse Microglia N9 (Cat#: NCL2110P073)
- Mouse Glioma Cell Line GL261-GFP (Cat#: NCL-2108P04)
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) (Cat#: NCL-2103-P49)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
