Amyotrophic Lateral Sclerosis Related Research Tools

Amyotrophic lateral sclerosis (ALS) is a disease that causes the death of the neurons controlling voluntary muscles. It is also known as Lou Gehrig's disease, Charcot's disease or motor neurone disease (MND). Over 17,000 people are estimated to be living with ALS in the United States, more commonly in whites, males, and people over the age of 60. The ALS symptoms include stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size.

ALS can be classified as familial or sporadic ALS. It has been shown that more than 20 genes are associated with familial ALS, of which four account for the majority of familial cases: C9orf72 (40%), SOD1 (20%), FUS (1-5%), and TARDBP (1-5%). Other genes include CHCHD10, SQSTM1, and TBK1. These genes can be grouped into three general categories: protein degradation, the cytoskeleton, and RNA processing.

Pathophysiology of ALS

Amyotrophic Lateral Sclerosis (ALS)

Creative Biolabs offers a range of research reagents needed for ALS investigation. Our products include monoclonal antibodies, polyclonal antibodies, labeled antibodies, recombinant proteins, analytical kits, cell lines, small molecule activators and inhibitors.

Related Genes of Amyotrophic Lateral Sclerosis (ALS)

Related Genes
SOD1 TARDBP FUS VEGFA SLC1A2 TNF ALS2	LAMC2 MAPT GFAP IGF1 CASP3 GDNF CSF2	IGFALS BDNF CNTF TRH CHAT MOTOR NEURON DEGENERATION

Related Pathways of Amyotrophic Lateral Sclerosis (ALS)

Related Pathways
SOD1 Pathogenesis Cell Death Neuron Death Aging Neuroprotection Regeneration Reflex Innervation RNA Processing Neurogenesis	Transport Localization Muscle Atrophy Secretion Translation Cognition Immune Response Cell Proliferation Autophagy Programmed Cell Death

Amyotrophic Lateral Sclerosis (ALS) Assay Service

For Research Use Only. Not For Clinical Use.

Target

Il-1β

SPP1

IL17RA

IL-6

VRK1

S100A9

STAT3 Phospho (Ser727)

ROBO4

TDP43

NEFM

CD4

PGP9.5

CD20

Nidogen-1

AMF

CD40

GDNF

CD29

Ubiquilin-2

C9orf72

ApoA4 (NT)

Mint-1

FTO

Ubiquitin

MOG

VLDLR

Munc18-1

PGR

AKT1

ADAR

S100 Beta

VCP