Blood Brain Barrier (BBB) related Cell Products

The blood-brain barrier (BBB) is a protective barrier between the central nervous system (CNS) and the blood. Its primary function is to maintain the stability of the brain environment, preventing harmful substances from entering the brain and allowing necessary nutrients and metabolic wastes to pass through. The blood-brain barrier consists of capillary endothelial cells, astrocytes, and pericytes. These cells work together through tight junctions, adhesion molecules, and transport proteins to form a highly specific barrier.

At Creative Biolabs, our BBB-related cell products provide scientists with powerful tools for neuroscience research, helping them gain a deeper understanding of the complexity of the blood-brain barrier and advance the development of treatments for neurological diseases. We offer a comprehensive range of BBB-related cell products. To learn more about our products or submit a project inquiry, please contact us today.

Product Overview

	3D Model Human Blood Brain Barrier Model 3D Human Blood Brain Barrier
	Brain Endothelial Cells Brain Microvascular Endothelial Cells (BMEC) derived from human, mouse, rat, and rabbit. Brain Vascular Pericytes derived from human, mouse, and rat. Immortalized Brain Endothelial Cells Immortalized Brain Endothelial Cellswith GFP
	Brain Fibroblasts Human Brain Vascular Adventitial Fibroblasts Brain Fibroblasts derived from human, mouse, and rat.
	Pericytes Human Brain Microvascular Pericytes (HBMVPCs) Human Leptomeningeal Pericytes Brain Microvascular Pericytes derived from mouse and rat. Immortalized Brain Pericytes with GFP
	Vascular Smooth Muscle Cells Rat Cerebral Artery Endothelial Cells Cerebral Arterial Vascular Smooth Muscle Cells derived from human, mouse, and rat.

Applications

The BBB is a complex system whose structure and function play a critical role in maintaining brain health and responding to disease. As research continues, we expect to better understand its mechanisms and develop new treatments for central nervous system disorders.

Although significant progress has been made in studying the BBB, many challenges remain. For example, how to effectively deliver drugs without disrupting the BBB and how to restore the function of the BBB under pathological conditions are the focus of current research. Future research may focus on the development of new therapeutic strategies to improve the treatment of neurodegenerative diseases and brain disorders.

For further information or to place an order, please contact us. Our products can provide strong support for a variety of applications, including drug screening, disease model establishment, and neuroprotection research.

References

1. Bang, Seokyoung, et al. "A low permeability microfluidic blood-brain barrier platform with direct contact between perfusable vascular network and astrocytes." Scientific reports 7.1 (2017): 8083.
2. Bull, Daniel, et al. "Generation of an hiPSC-Derived Co-Culture system to assess the effects of neuroinflammation on blood–brain barrier integrity." Cells 11.3 (2022): 419.
3. Xu, Lingling, et al. "Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2." Cell reports 41.8 (2022).
4. Rustenhoven, Justin, et al. "An anti-inflammatory role for C/EBPδ in human brain pericytes." Scientific reports 5.1 (2015): 12132.
5. Distributed under Open Access license CC BY 4.0, without modification.
6. Bacakova, Lucie, et al. "Vascular smooth muscle cells (VSMCs) in blood vessel tissue engineering: the use of differentiated cells or stem cells as VSMC precursors." Muscle Cell and Tissue-Current Status of Research Field. London, UK: IntechOpen (2018): 289-307. Distributed under Open Access license CC BY 3.0, without modification.