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Creative Biolabs

Beta Amyloid Antibodies

The primary component of amyloid plaques identified in the brains of Alzheimer's disease (AD) patients is amyloid beta, often known as Aβ or Abeta, which is a group of protein peptides produced when β- and γ-secretases cleave the amyloid precursor protein (APP). Amyloid plaques are formed by the spontaneous assembly of monomeric Aβ into soluble Aβ oligomers, that aggregate to form insoluble fibrils.

Aβ Overview

Aβ is 40-43 amino acids long and can be produced by a variety of cells. They are circulating in the brain's interstitial fluid, cerebrospinal fluid, and blood. While some Aβ are in a free state, the majority are attached to chaperone molecules. The Aβ1-40 and Aβ1-42 subtypes are the most prevalent in humans. Aβ1-40 is found at levels 10 and 1.5 times greater in human cerebrospinal fluid and blood, respectively, than Aβ1-42. Aβ1-42 exhibits higher toxicity and aggregation potential, resulting in the formation of the core of Aβ precipitation and inducing neurotoxic consequences.

Aβ Immunotherapy

Scientists are currently developing therapies to treat individuals at risk for AD before or in the early stages of cognitive decline, hoping to prevent or delay the onset of the disease. These include Aβ immunotherapy, which uses anti-Aβ antibodies (or fragments thereof) to reduce Aβ aggregation and deposition in the AD brain. Anti-Aβ antibodies can function in three ways:

  • By decreasing the generation of Aβ
  • By preventing Aβ from aggregating or breaking down Aβ aggregates
  • By neutralizing toxic Aβ aggregates

Antibody Recommendations for Beta-Amyloid Research

Creative Biolabs offers a range of Aβ-related validated antibodies for Western blotting, immunofluorescence, ELISA, flow cytometry, and immunoprecipitation. If you would like to know more about Aβ-related antibodies, please click on the form below or contact us directly. We will be in touch within 24 hours, if not sooner!

APP
Target Cat. No Product Name Host Application
Aβ 1-5 NRP-0422-P946 Anti-Amyloid Beta 1-5 Antibody Mouse WB; ELISA; In Vitro
Aβ 3-7 NRP-0422-P947 Anti-Amyloid Beta 3-7 Antibody Mouse WB; ELISA; In Vitro
Aβ 1-12 NRP-0422-P950 Anti-Amyloid Beta 1-12 Antibody Mouse WB; ELISA; In Vitro
Aβ 1-15 NRP-0422-P867 Anti-Amyloid Beta 1-15 Antibody Humanized In Vivo
NRP-0422-P2292 Anti-Amyloid Beta 1-15 Antibody Mouse Inhib; In Vitro; In Vivo
NRZP-1022-ZP2792 Anti-Amyloid Beta BBB Shuttle Antibody Human Inhib; In Vitro; In Vivo
NRP-0422-P971 Anti-Amyloid Beta 1-15 Antibody Mouse WB; ELISA
Aβ 16-28 NRP-0422-P968 Anti-Amyloid Beta 16-28 Antibody Mouse In Vitro; ELISA
Aβ 19-22 NRP-0422-P969 Anti-Amyloid Beta 19-22 Antibody Mouse WB; In Vitro;In Vivo
Aβ 1-40 NRP-0422-P941 Anti-Amyloid Beta 1-40 Antibody Mouse WB; ELISA; In Vitro
NRP-0422-P943 Anti-Amyloid Beta 1-40 Antibody Humanized WB; ELISA; In Vitro
NRP-0422-P954 Anti-Amyloid Beta 1-40 Antibody Mouse WB; ELISA; In Vitro; IHC
Aβ 1-42 NRP-0422-P955 Anti-Amyloid Beta 1-42 Antibody Mouse WB; ELISA; In Vitro; IHC
NRP-0422-P958 Anti-Amyloid Beta 1-42 Antibody Chimeric WB; ELISA; In Vitro; IHC
NRP-0422-P976 Anti-Amyloid Beta 1-42 Antibody Mouse WB; In Vitro; In Vivo
NRP-0422-P2274 Anti-Amyloid Beta 1-42 Antibody Mouse ELISA; In Vitro; In Vivo
Aβ 2-40 NRZP-1022-ZP3652 Anti-Amyloid Beta 2-40 Amyloid Beta 3-40 APP BBB Shuttle Antibody Mouse WB; ELISA; In Vitro; IHC
Aβ 33-42 NRP-0422-P952 Anti-Amyloid Beta 33-42 Antibody Mouse WB; ELISA; In Vitro
NRZP-1022-ZP4183 Anti-Amyloid Beta Antibody Human In Vitro

See all Aβ antibodies

Cat. No Product Name Host Application
NRZP-0922-ZP1579 Anti-APP Antibody, Clone CBP12890 Rabbit WB; IP; IHC
NRZP-0922-ZP1580 Anti-APP Antibody, Clone CBP12891 Rabbit IF
NRZP-0922-ZP1581 Anti-Phospho-APP (Thr668) Antibody, Clone CBP12892 Rabbit WB; IP
NRZP-0922-ZP1588 Anti-APP Antibody, Clone CBP12899 Rabbit IHC
NRZP-0922-ZP1592 Anti-APP Antibody, Clone CBP12903 Rabbit IF
NAB20121048LS Mouse Anti-Human APP Monoclonal Antibody (CBP4029) Mouse WB
NRZP-0922-ZP1595 Anti-APP Antibody, Clone CBP12906 Rabbit WB; IP
NAB20101747CR Mouse Anti-APP Monoclonal Antibody (CBP2673) Mouse IHC; WB; ELISA
NAB-08-PZ100 Rabbit Anti-Human APP Monoclonal Antibody (CBP1638) Rabbit ICC; IF; FC

See all APP antibodies

For Research Use Only. Not For Clinical Use.

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