Beta Amyloid Antibodies
The primary component of amyloid plaques identified in the brains of Alzheimer's disease (AD) patients is amyloid beta, often known as Aβ or Abeta, which is a group of protein peptides produced when β- and γ-secretases cleave the amyloid precursor protein (APP). Amyloid plaques are formed by the spontaneous assembly of monomeric Aβ into soluble Aβ oligomers, that aggregate to form insoluble fibrils.
Aβ Overview
Aβ is 40-43 amino acids long and can be produced by a variety of cells. They are circulating in the brain's interstitial fluid, cerebrospinal fluid, and blood. While some Aβ are in a free state, the majority are attached to chaperone molecules. The Aβ1-40 and Aβ1-42 subtypes are the most prevalent in humans. Aβ1-40 is found at levels 10 and 1.5 times greater in human cerebrospinal fluid and blood, respectively, than Aβ1-42. Aβ1-42 exhibits higher toxicity and aggregation potential, resulting in the formation of the core of Aβ precipitation and inducing neurotoxic consequences.
Aβ Immunotherapy
Scientists are currently developing therapies to treat individuals at risk for AD before or in the early stages of cognitive decline, hoping to prevent or delay the onset of the disease. These include Aβ immunotherapy, which uses anti-Aβ antibodies (or fragments thereof) to reduce Aβ aggregation and deposition in the AD brain. Anti-Aβ antibodies can function in three ways:
- By decreasing the generation of Aβ
- By preventing Aβ from aggregating or breaking down Aβ aggregates
- By neutralizing toxic Aβ aggregates
Antibody Recommendations for Beta-Amyloid Research
Creative Biolabs offers a range of Aβ-related validated antibodies for Western blotting, immunofluorescence, ELISA, flow cytometry, and immunoprecipitation. If you would like to know more about Aβ-related antibodies, please click on the form below or contact us directly. We will be in touch within 24 hours, if not sooner!
Target | Cat. No | Product Name | Host | Application |
---|---|---|---|---|
Aβ 1-5 | NRP-0422-P946 | Anti-Amyloid Beta 1-5 Antibody | Mouse | WB; ELISA; In Vitro |
Aβ 3-7 | NRP-0422-P947 | Anti-Amyloid Beta 3-7 Antibody | Mouse | WB; ELISA; In Vitro |
Aβ 1-12 | NRP-0422-P950 | Anti-Amyloid Beta 1-12 Antibody | Mouse | WB; ELISA; In Vitro |
Aβ 1-15 | NRP-0422-P867 | Anti-Amyloid Beta 1-15 Antibody | Humanized | In Vivo |
NRP-0422-P2292 | Anti-Amyloid Beta 1-15 Antibody | Mouse | Inhib; In Vitro; In Vivo | |
NRZP-1022-ZP2792 | Anti-Amyloid Beta BBB Shuttle Antibody | Human | Inhib; In Vitro; In Vivo | |
NRP-0422-P971 | Anti-Amyloid Beta 1-15 Antibody | Mouse | WB; ELISA | |
Aβ 16-28 | NRP-0422-P968 | Anti-Amyloid Beta 16-28 Antibody | Mouse | In Vitro; ELISA |
Aβ 19-22 | NRP-0422-P969 | Anti-Amyloid Beta 19-22 Antibody | Mouse | WB; In Vitro;In Vivo |
Aβ 1-40 | NRP-0422-P941 | Anti-Amyloid Beta 1-40 Antibody | Mouse | WB; ELISA; In Vitro |
NRP-0422-P943 | Anti-Amyloid Beta 1-40 Antibody | Humanized | WB; ELISA; In Vitro | |
NRP-0422-P954 | Anti-Amyloid Beta 1-40 Antibody | Mouse | WB; ELISA; In Vitro; IHC | |
Aβ 1-42 | NRP-0422-P955 | Anti-Amyloid Beta 1-42 Antibody | Mouse | WB; ELISA; In Vitro; IHC |
NRP-0422-P958 | Anti-Amyloid Beta 1-42 Antibody | Chimeric | WB; ELISA; In Vitro; IHC | |
NRP-0422-P976 | Anti-Amyloid Beta 1-42 Antibody | Mouse | WB; In Vitro; In Vivo | |
NRP-0422-P2274 | Anti-Amyloid Beta 1-42 Antibody | Mouse | ELISA; In Vitro; In Vivo | |
Aβ 2-40 | NRZP-1022-ZP3652 | Anti-Amyloid Beta 2-40 Amyloid Beta 3-40 APP BBB Shuttle Antibody | Mouse | WB; ELISA; In Vitro; IHC |
Aβ 33-42 | NRP-0422-P952 | Anti-Amyloid Beta 33-42 Antibody | Mouse | WB; ELISA; In Vitro |
NRZP-1022-ZP4183 | Anti-Amyloid Beta Antibody | Human | In Vitro |
Cat. No | Product Name | Host | Application |
---|---|---|---|
NRZP-0922-ZP1579 | Anti-APP Antibody, Clone CBP12890 | Rabbit | WB; IP; IHC |
NRZP-0922-ZP1580 | Anti-APP Antibody, Clone CBP12891 | Rabbit | IF |
NRZP-0922-ZP1581 | Anti-Phospho-APP (Thr668) Antibody, Clone CBP12892 | Rabbit | WB; IP |
NRZP-0922-ZP1588 | Anti-APP Antibody, Clone CBP12899 | Rabbit | IHC |
NRZP-0922-ZP1592 | Anti-APP Antibody, Clone CBP12903 | Rabbit | IF |
NAB20121048LS | Mouse Anti-Human APP Monoclonal Antibody (CBP4029) | Mouse | WB |
NRZP-0922-ZP1595 | Anti-APP Antibody, Clone CBP12906 | Rabbit | WB; IP |
NAB20101747CR | Mouse Anti-APP Monoclonal Antibody (CBP2673) | Mouse | IHC; WB; ELISA |
NAB-08-PZ100 | Rabbit Anti-Human APP Monoclonal Antibody (CBP1638) | Rabbit | ICC; IF; FC |
- NeuroMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- NeuroMab™ Anti-Integrin αvβ8 BBB Shuttle Antibody(NRZP-1222-ZP1218) (Cat#: NRZP-1222-ZP1218)
- NeuroMab™ Anti-EPHB2 Antibody(NRP-0422-P1220) (Cat#: NRP-0422-P1220)
- NeuroMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P2275) (Cat#: NRP-0422-P2275)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- NeuroMab™ Anti-SEZ6 Antibody(NRP-0422-P515) (Cat#: NRP-0422-P515)
- NeuroMab™ Anti-Alpha Synuclein Antibody(NRP-0422-P614) (Cat#: NRP-0422-P614)
- NeuroMab™ Anti-F-Spondin/SPON1 Antibody, Clone N24875P (CBP11839) (Cat#: NRZP-0822-ZP4740)
- NeuroMab™ Anti-Tau Antibody(NRP-0422-P1684) (Cat#: NRP-0422-P1684)
- Human Brain Microvascular Endothelial Cells (Cat#: NCL-2103-P133)
- iNeu™ Human Midbrain Dopaminergic Neurons (Cat#: NCL-21P6-003)
- Mouse Retinal Ganglion Cell Line RGC-5 (Cat#: NCL2110P154)
- Mouse Hippocampal Neuron Cell HT22 (Cat#: NCL2110P001)
- iNeu™ Human Schwann Cell (Cat#: NCL-2103-P63)
- Rat Immortalized Retinal Muller Cell Line rMC-1 (Cat#: NCL-2106-S93)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- C57 Brain Cortex Neurons [Mouse] (Cat#: NCC20-9PZ48)
- Human Neurons Isolated from Cortex (Cat#: NCL-21P6-023)
- Human Astrocytes (Cat#: NCC20-9PZ01)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- AAV2/9-hSyn-Flpo-EGFP-WPRE-pA (Cat#: NTA-2012-ZP149)
- Dextran, Cy5 Labeled, 2000 kDa (Cat#: NRZP-0722-ZP22)
- PRV-CAG-EGFP (Cat#: NTA-2011-ZP14)
- pAAV-hSyn-DIO-XCaMP-R-WPRE (Cat#: NTA-2012AD-P508)
- rAAV-CAG-DIO-G-Flamp1 (Cat#: NRZP-0722-ZP719)
- pAAV-syn-FLEX-jGCaMP8m-WPRE (Cat#: NTA-2106-P065)
- Dextran, NHS Activated, 40 kDa (Cat#: NRZP-0722-ZP124)
- AAV-mDLX-CRE-tdTomato (Cat#: NRZP-0622-ZP721)
- pAAV-syn-jGCaMP8f-WPRE (Cat#: NTA-2106-P061)
- pAAV-syn-FLEX-jGCaMP8s-WPRE (Cat#: NTA-2106-P066)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP509)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)