Cerebral Aneurysm Related Research Tools

The cerebral aneurysm is an abnormal bulge or ballooning of an artery in the brain that can put pressure on the surrounding nerves and brain tissues. It is also known as an intracranial aneurysm or brain aneurysm. There are three types of cerebral aneurysms: saccular aneurysms, fusiform aneurysms and dissecting aneurysms. Saccular aneurysms are the most common type, accounting for 90% of cerebral aneurysm cases.

A cerebral aneurysm accompanies robust structural changes in the vascular wall. Hemodynamic stress, inflammatory responses, extracellular matrix defects and degeneration have been suggested as the key components leading to the structural fragility in the arterial wall. However, the exact pathogenesis of cerebral aneurysm formation, growth, and rupture remains to be discovered.

Fig.1 Structural alteration of a cerebral aneurysm.

Creative Biolabs provides cerebral aneurysms related reagents, such as recombinant proteins, antibodies, cell lines and analytical kits. These high-quality products can be used in genetic, imaging, and laboratory tests and help to study the natural course and pathophysiology of cerebral aneurysms.

We are here to offer an opportunity to better identify aneurysms that have a high risk of rupture.

Pathophysiological Factors Involved in Aneurysm Formation

Molecular and histological changes
Endothelial cell	Endothelial cell apoptosis Pro-inflammatory endothelial cell Breakdown of endothelial barrier E-selectin, P-selectin, VCAM-1, ICAM-1
Smooth muscle cell	Phenotypic switching from contractile to inflammatory type Pro-inflammatory vascular smooth muscle cell Smooth muscle cell apoptosis and degeneration
Inflammation	Infiltration of macrophages, neutrophils, T cell and mast cell NF-kB, TNFα, MCP-1, IL-1p, IL-8, IL-17 COX2, PGE2, angiotensin II, NO, TLR-4 MMP 1, 2, 9 and Cathepsins IgM, IgG Complement (C3a, C5a)
Extracellular matrix	Alteration of collagen to elastic ratio Breakdown of collagen and elastin cross-link Matrix degradation
Internal elastic lamina	Fragmentation, and wavy appearance Break down and degradation

For Research Use Only. Not For Clinical Use.

Target

MSR1

ERAB

PSD 93

Laminin alpha 4/LAMA4

Nogo

Neuroligin 3

Adiponectin

Mitofusin 2

MEF2A

Mint-1

AVPR1A

CSN7b

SHIP-2

Dab1

iNOS

GFAP

Sarcoplasmic Reticulum

GBA

LAMP1

PGP9.5

NUDC

SNAP29

Visfatin

Gephyrin

Tachykinin

CRMP2

Huntingtin

APP

Hemojuvelin

Galectin 3

Gemin 2

Proinsulin

Premade Viruses

Target: Munc13-1

iNeuMab™ Mouse Anti-Munc Monoclonal Antibody (CBP4846) [CAT#: NAB-2103-P490]

Host Species:: Mouse

Species Reactivity:: Human

Applications:: WB; IP; IF; IHC-P; ELISA

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