Epilepsy and Seizures Related Antibodies

Epilepsy is a noncommunicable chronic brain disease that affects roughly 50 million people globally and is defined as two or more unexplained seizures. Epileptic seizures are caused by an abnormal discharge of a group of brain cells, which is triggered by neurons in the central nervous system transmitting incorrect information. The clinical manifestations of epileptic seizures are complicated and diverse, involving paroxysmal motor, sensory, autonomic nervous system, awareness, and mental abnormalities. This is because there are multiple starting sites and transmission pathways of aberrant discharges.

Key Factors of HD

Genetic factors, which are an important trigger of idiopathic epilepsy, are one of the major causes of epilepsy. Ion channels and neurotransmitter receptors are the main groups of genes associated with the etiology of epilepsy that have been found to be implicated. Mutations in these genes may reduce inhibitory mechanisms or make neurons hyperexcitable, resulting in epilepsy recurrence. SCN1A, SCN2A, KCNQ2, CACNA1A, and CACNA1A are voltage-gated ion channel genes linked to epilepsy. Mutations in some GABAA receptor subunit genes (GABRA1, GABRB2, GABRB3, GABRD, and GABRG) have been linked to a variety of genetic epilepsies. Aside from genetic impacts, the disease may be caused by a number of variables, such as head trauma, brain issues, infections, prenatal traumas, and developmental disorders.

Creative Biolabs' dedicated antibody development team collaborates with epilepsy and seizure research teams to develop NeuroMab™ antibody products that will help you with your epilepsy and seizure research. Please use the form below to learn more about the relevant antibodies, or contact us directly, and we will get back to you as soon as possible.