GBA Antibodies
The glucocerebrosidase (GBA) gene mutation is a very important and common risk factor for Parkinson's disease (PD). Some Gaucher disease (GD) patients and GBA mutation carriers are prone to develop PD. In addition, the frequency of PD patients carrying GBA mutations is also greatly increased. In most PD patients, GBA mutations are more common than other PD-related genes.
Elucidating the mechanism of the association between GBA mutations and PD will provide new and important insights into the treatment of PD. Current hypotheses and models have significant limitations, so we need to combine cell biology, neuropathology, and genetics to further study GBA-related PD and elucidate its pathogenesis and other risk factors that promote PD. Our antibodies are powerful tools for your research to propose new therapeutic strategies for this common disease and other neurodegenerative disorders, and to mitigate or prevent the progression of these diseases.
GBA Mutations and PD
- GBA mutation promotes α-synuclein aggregation. Mutant GBA and α-synuclein co-localize in protein aggregates in the brains of PD patients. Another study found that in brain samples from PD patients carrying GBA mutations, GBA was present in 33% to 90% of Lewy bodies, with an average of 75%, while in PD patients without GBA mutations, GBA was present in less than 10% of Lewy bodies.
- GBA mutation influences the autophagy-lysosome pathway. Mice with the homozygous GBA mutation V394L and deficiency of protein kinase C are a model for GD. By observing the axons in the mouse brain, the researchers found some aggregates in the axons where the autophagy markers LAMP-2 and p62 were present, suggesting that GBA mutations could lead to impaired autophagy and cause axonal degeneration.
- GBA mutation affects the ubiquitin-proteasome system. PARK2 encodes the E3 ubiquitin ligase parkin. Mutations in this gene lead to parkin dysfunction, which is associated with juvenile-onset autosomal inherited PD. Studies have shown that both wild-type GBA and the N370S mutant GBA can interact with parkin, suggesting that the interaction between mutant GBA and parkin prevents parkin from interacting with its substrate, thereby disrupting the ubiquitin-proteasome system and ultimately leading to endoplasmic reticulum stress and cell death.
Fig.1 Possible mechanism for the link between GBA mutation and PD.1
GBA Antibodies Selection Guide
Choose the most appropriate GBA antibody for your research from Creative Biolabs' GBA antibodies library, which is suitable for a variety of applications and can bind to GBA in human, rat, and mouse. If you can't find the antibody you need, contact us now to develop custom antibodies for specific targets, species, and applications.
Cat. No | Product Name | Host | Application |
NAB-0720-Z5453 | Rabbit Anti-GBA Monoclonal Antibody (CBP3048) | Rabbit | WB; IHC-P |
NAB-0720-Z5456 | Rabbit Anti-GBA Monoclonal Antibody (CBP3051) | Rabbit | WB; IHC-P |
NAB-0720-Z5458 | Mouse Anti-GBA Monoclonal Antibody (CBP3053) | Mouse | WB; IHC-P; IHC-Fr; ICC; IF |
NRZP-0223-ZP222 | Anti-GBA/Glucosylceramidase Monoclonal Antibody, (CBP17909) | Rabbit | WB |
Reference
- Smith, Laura, and Anthony HV Schapira. "GBA variants and Parkinson disease: mechanisms and treatments." Cells 11.8 (2022): 1261. Distributed under Open Access license CC BY 4.0, without modification.
- iNeuMab™ Anti-F-Spondin/SPON1 Antibody, Clone 3F4 (Cat#: NRZP-0822-ZP4740)
- iNeuMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP1887) (Cat#: NAB-08-PZ735)
- iNeuMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- iNeuMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- iNeuMab™ Mouse Anti-EFNB2 Monoclonal Antibody (CBP1159) (Cat#: NAB-0720-Z4396)
- iNeuMab™ Mouse Anti-SHANK3 Monoclonal Antibody (CBP929) (Cat#: NAB-0720-Z3477)
- Rat Microglia Cell Line HAPI, Immortalized (Cat#: NCL2110P015)
- Human Brain Astroblastoma U-87 MG (Cat#: NCL2110P117)
- Human Dental Pulp Stem Cells (Cat#: NRZP-1122-ZP113)
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- Human Brain Vascular Adventitial Fibroblasts (Cat#: NCL-21P6-014)
- Human Brain Microvascular Endothelial Cells (Cat#: NCL-2103-P133)
- Human Astrocytes, Immortalized (Cat#: NCL-2105-P182-AM)
- Green Fluorescent Alpha-synuclein Cell Line (Cat#: NCL2110P209)
- Mouse Glioma Cell Line GL-261-Luc (Cat#: NCL-2108P06)
- iNeu™ Human Neural Stem Cell Line (Cat#: NCL200552ZP)
- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged (Cat#: NEP-0621-R0133)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged (Cat#: NEP-0421-R0232)
- Tau Antisense Oligonucleotide (IONIS-MAPTRx) (Cat#: NV-2106-P29)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)