Guillain-Barré Syndrome Related Research Tools

Guillain-Barré syndrome (GBS), the most common cause of acute flaccid paralysis, is a rare condition in which a person’s immune system attacks the peripheral nerves. The symptoms of Guillain–Barré syndrome are numbness, tingling, pain and weakness of the legs and arms.

Guillain-Barré syndrome is due to the nerve dysfunction by an immune attack on the nerve cells of the peripheral nervous system. Different types of Guillain-Barré syndrome are categorized by different types of immune attack. For instance, the demyelinating variant is characterized by the damage to the myelin sheath from white blood cells preceded by the activation of a group of blood proteins. The axonal variant is mediated by the IgG antibodies and the complement components against the cell membrane covering the axons.

Fig.1 Immune system attacks nerves in the body with Guillain-Barre syndrome.

Creative Biolabs offers a series of research tools needed to study the mechanisms of Guillain-Barré syndrome. Some tools, such as autoimmune neuritis animal models, kinase enzymes and complement inhibitors, proteins and antibodies, have been verified in laboratory tests.

Pathways related to Guillain-Barre Syndrome

Super pathways	Genes
Measles	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, FAS
Herpes simplex virus 1 infection	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, FAS
Allograft rejection	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, FAS, CD40LG
NF-kappa B signaling	TNFRSF1B, TNF, FAS, CD79A, CD40LG
ICos-ICosL pathway in T-helper cell	HLA-DRB1, HLA-DQB1, HLA-DQA1, CD40LG

Cellular components related to Guillain-Barre Syndrome

Cellular components	Genes
External side of plasma membrane	TNF, MOG, HLA-DRB1, CD79A, CD40LG
Membrane raft	TNFRSF1B, TNF, FAS, CD79A
Endocytic vesicle membrane	HLA-DRB1, HLA-DQB1, HLA-DQA1
Myelin sheath	PMP2, MPZ, MBP

For Research Use Only. Not For Clinical Use.

Target

Netrin G1

Sarcoplasmic Reticulum

Afadin

Presenilin 1

HAP1

PACRG

Mint-1

IL-1α

SPOCK1

Glutathione Synthetase

nNOS

FABP3

APPL

LRRK2

CrkL

SEMA3D

YY1

Neurolysin

Myelin

LIN7A

UNC45

Serine Racemase

LNX

IGF1 Receptor

PHGDH

PTPRN

BAX

Niemann Pick C2

FABP4

DARPP32

Insulin Receptor

Guillain-Barré Syndrome Related Research Tools

Target

The Spectrum of Stem Cell-Based Neuronal Models and Their Fit for Purpose