Modulators

Understanding how cells behave allows us to see how they are normally regulated when they are in a normal state. These findings can help us better understand how these mechanisms are altered during the beginning and progression of neurodegenerative diseases and identify new biomarkers and therapeutic targets. Creative Biolabs offers a range of modulators, including compounds (inhibitors and agonists) and aptamers, which are valuable tools for researchers.

Compounds

Small molecule compounds mainly affect how proteins work. Right now, small molecule compounds are mostly used to target enzymes, ion channels, and receptors. The role of small molecule compounds can vary depending on the type of target. Even though small molecule compounds are grouped into categories like enzyme inhibitors, ion channel blockers, and receptor agonists/antagonists based on their target types, these divisions aren't always clear-cut because some targets have multiple functions.

Aptamers

Aptamers are oligonucleotides or peptides that have a high degree of selectivity and affinity when binding to particular target molecules. Their strong affinity and specificity have earned them the moniker "antibody alternatives". Aptamers are naturally found in riboswitches, but they may also be manufactured through repeated in vitro selections and bind to a wide range of molecular targets, including small molecules, proteins, nucleic acids, and cells.

To further advance the treatment of Alzheimer's disease, numerous efforts have been made by researchers to create inhibitors of amyloid aggregation. Aptamers are a prospective inhibitor of Aβ aggregation due to their ease of modification, cost-effectiveness, repeatability, biocompatibility, stability, and Aβ selectivity.

Fig 1 N2 and E2 RNA aptamers can inhibit aggregation and fibrillation of Aβ peptides. (Takahashi, et al., 2009)

Fig.1 N2 and E2 RNA aptamers can inhibit aggregation and fibrillation of Aβ peptides. A) TEM images of Aβ 40 aggregates after incubation for 19 h in the absence of RNA aptamers and in the presence of N2 and E2 RNA aptamers.¹

Applications

Modulators can help you with:

Answer questions on the involvement of specific signaling nodes in disease.
Investigate the mechanism of action of disease drugs by inhibiting the main pathway to observe the activation of alternative pathways.
Identify protein interactions or kinase substrates by activating or inhibiting individual signaling nodes.

If the product you're looking for isn't listed, please contact us immediately. Our experts can help you find a good alternative that can be used as an inhibitor, agonist, delivery tool, and in many research applications. Kindly reach out to us via phone or email, and we will be happy to help you locate the ideal product for your needs.

Reference

Takahashi, Tsuyoshi, Kosuke Tada, and Hisakazu Mihara. "RNA aptamers selected against amyloid β-peptide (Aβ) inhibit the aggregation of Aβ." Molecular Biosystems 5.9 (2009): 986-991.

For Research Use Only. Not For Clinical Use.

Target

Aptamers

PDGFRB

SPP1

Tenascin C

EGFRvIII

AXL

IL-17

Transferrin Receptor

Eph Receptor A2

AMPA

EphB3/2

BACE1

Factor IXa

Nogo A

PRNP

FOLH1

EGFR

CD133

EDB-FN

EpCAM

PTK7

Compound

Amyloid Beta