Muscular Dystrophy Related Research Tools

Muscular dystrophy (MD) is an inherited genetic condition that gradually causes the weakening of muscles. The MDs are caused by mutations in a large number of genes with different functions, encoding proteins of the contractile apparatus, structural proteins, enzymes or nuclear proteins. The most commonly encountered forms of the diseases in adults are myotonic dystrophy (MD), facioscapulohumeral muscular dystrophy (FSHD) and the large group of limb-girdle muscular dystrophy (LGMD). The most common childhood form is Duchenne muscular dystrophy (DMD).

The genomic mutations in MDs exert their pathogenicity at the level of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). Therefore, the primary molecular targets in MDs are the affected genes and/or their respective downstream targets. Currently, most of the therapeutic strategies are focused on the mutated gene products or their downstream targets. Evidence has shown that the structural linkage between the muscle extracellular matrix and the cytoskeleton is crucial in preventing the progression of MD. The primary mutations of enzymes involved in the protein glycosylation pathways have shown to disrupt the matrix-cell interaction in a certain group of MDs.

In the past several years, viral and non-viral gene therapy methodologies based on adeno-associated viruses, naked plasmid delivery, antisense oligonucleotides, and oligonucleotide-mediated gene editing have moved from the laboratories to the clinical studies. Creative Biolabs offers comprehensive products as well as high-quality customized services for our clients. We have some of the best products and packages to aid your MDs research.

Summary of the Popular Objects in Muscular Dystrophy

Calpain protease inhibitor	Collagen VI	Creatine
Dystrophin	Follistatin	Fukutin
Fukutin-related protein (FKRP)	IGF1	Integrin α7β1
ISS-N1	Laminin-2	LARGE
Leukemia inhibitory factor (LIF)	NFκB	NOX
P2RX7 purinoceptor	POMT1	POMT2
ROS	ROX	RyR1
TNFR	TNFα	TRPV2
β-Sarcoglycan	Corticosteroids prednisone	Leukemia inhibitory factor (LIF)

For Research Use Only. Not For Clinical Use.

Target

Neurofilament L

Cathepsin D

NEUROG2

PRNP

CARD9

CDK1

RUNX3

Stathmin 1

FE65

NPY2

Apo E

SHANK3

GRID1

Fetuin A

Galectin 9

Amyloid Fibril

BAX

4E-BP1

SRGAP1

Proinsulin

HTR3C

versican

SOX2

CAV BETA 2

NrCAM

GOSR1

CacyBP

SORT1

Neurabin 1

Nogo

RUNX2

GAD1