Neural Crest Stem Cell Marker Related Research Reagents
Neural crest cells (NCCs) are the pluripotent stem cells unique to vertebrates and produced by embryonic ectoderm germ layers, which can differentiate into different cell types (such as melanocytes, peripheral and enteric neurons and glial cells) and give rise to multiple tissues and organs (include craniofacial cartilage and bones, smooth muscle). The emergence of neural crest is important in the evolution of vertebrates because many of its structural derivatives are characteristic of the vertebrate clade. Because of its contribution to a variety of cell lineages, understanding the molecular mechanism of neural crest formation is very important for researchers to understand human diseases. Studies have shown that abnormal neural crest development can cause neuro spinal neuropathy, including frontal nose dysplasia, Waardenburg-Shah syndrome and DiGeorge syndrome.
Neural Crest Induction
The molecular cascade of events is involved in establishing the migration and pluripotency characteristics of neural crest cells. The gene regulation network can be subdivided into four sub-networks, including Inductive signals, Neural plate border specifiers, Neural crest specifiers, and Neural crest effector genes. The putative neural rest gene regulation network in the vertebrate neural plate border kicks in.
Fig.1 Neural crest gene-regulatory network.
Clinical Significance
Neural crest cells have been shown to be associated with multiple neurocristopathies which result from the abnormal specification, migration, differentiation or death of neural crest cells throughout embryonic development. This group of diseases includes various congenital malformations that affect many newborns. In addition, their appearance is due to genetic defects that affect the formation of neural crest and the action of teratogens.
Waardenburg's Syndrome - Waardenburg's syndrome is a neurocristopathy that results from defective neural crest cell migration. The main characteristics of this condition include piebaldism and congenital deafness. The piebaldism is caused by a total absence of neural crest-derived pigment-producing melanocytes.
Hirschsprung's Disease - In healthy development, neural crest cells migrate into the gut and form the enteric ganglia. Genes that play a role in the healthy migration of these neural crest cells to the intestine. When this signal is disrupted in mice, ganglion disease or lack of these enteric ganglia can occur.
DiGeorge Syndrome - The symptoms of DiGeorge syndrome include congenital heart defects, facial defects, and some neurological and learning disabilities.
Treacher Collins Syndrome - Treacher Collins Syndrome (TCS) is caused by a missense mutation in the TCOF1 gene, which causes neural Crest cells to undergo apoptosis during embryogenesis.
Creative Biolabs provides a series of research tools needed to study the function of neural crest cells. Our product portfolio includes cell lines from multiple species, optimized serum-free media, reliable cell differentiation media, media additives, and key cell markers and research antibodies.
Please browse the options below to take a deeper look at the tools you need for your research.
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Mouse monoclonal Antibody to SOX9
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P; Protein Array
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 570
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Mouse monoclonal Antibody to SOX9
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IHC-P; Protein Array
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 546
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Rabbit monoclonal Antibody to SOX9 - C-terminal
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- FC; ICC; IF; WB
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 538
![](static/images/product/product-icon-neural-antibodies.png)
Mouse monoclonal Antibody to SOX9
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; ELISA; IHC-P; ICC; IF; FC; IP
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 488
![](static/images/product/product-icon-neural-antibodies.png)
SOX9 Rabbit Monoclonal Antibody 0.02% Sodium azide
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- ICC; IF
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 471
![](static/images/product/product-icon-neural-antibodies.png)
SOX9 Rabbit Monoclonal Antibody 0.02% Sodium azide
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- ICC; IF
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 470
![](static/images/product/product-icon-neural-antibodies.png)
SOX9 Rabbit Monoclonal Antibody 0.02% Sodium azide
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- ICC; IF
- Conjugation:
- Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 442
- NeuroMab™ Anti-GARP Antibody(NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- NeuroMab™ Anti-pTau Antibody(NRP-0422-P1719) (Cat#: NRP-0422-P1719)
- NeuroMab™ Anti-EPHB2 Antibody(NRP-0422-P1220) (Cat#: NRP-0422-P1220)
- NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody(NRZP-1022-ZP4050) (Cat#: NRZP-1022-ZP4050)
- NeuroMab™ Anti-GD2 Antibody(NRZP-1222-ZP767) (Cat#: NRZP-1222-ZP767)
- NeuroMab™ Anti-PVRIG Antibody(NRP-0422-P792) (Cat#: NRP-0422-P792)
- NeuroMab™ Rabbit Anti-Alpha-synuclein (CBP1631) (Cat#: NAB-08-PZ079)
- NeuroMab™ Anti-CD20 Antibody(NRP-0422-P1230) (Cat#: NRP-0422-P1230)
- NeuroMab™ Mouse Anti-LRP1 Monoclonal Antibody (CBP3363) (Cat#: NAB-0720-Z6479)
- NeuroMab™ Anti-PVRIG Antibody(NRP-0422-P1803) (Cat#: NRP-0422-P1803)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
- Human CMEC/D3 Cell Line, Blood-Brain Barrier Model (Cat#: NCL-2108-P020)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- Human Microglia Cell Line HMC3, Immortalized (Cat#: NCL-2108P38)
- Mouse Microglia from C57BL/6 (Cat#: NCL-21P6-082)
- Rat Retinal Muller Cell Line, Immortalized (Cat#: NCL-21P6-192)
- Rat Muller Cell (Cat#: NCL2110P040)
- Green Fluorescent BACE1 Cell Lines (Cat#: NCL2110P214)
- Mouse Glioma Cell Line GL261-GFP (Cat#: NCL-2108P04)
- Mouse Microglia N9 (Cat#: NCL2110P073)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Beta Amyloid (1-40), Aggregation Kit, TTF Assay (Cat#: NRZP-0323-ZP199)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Alpha-Synuclein Aggregation Assay Kit (Cat#: NRZP-1122-ZP37)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- pAAV-syn-FLEX-jGCaMP8m-WPRE (Cat#: NTA-2106-P065)
- Dextran, NHS Activated, 40 kDa (Cat#: NRZP-0722-ZP124)
- AAV2/9-hSyn-Flpo-EGFP-WPRE-pA (Cat#: NTA-2012-ZP149)
- Dextran-FITC (Cat#: NTA-2011-ZP110)
- Dextran-CYanine5.5 (Cat#: NTA-2011-ZP118)
- pAAV-syn-FLEX-jGCaMP8s-WPRE (Cat#: NTA-2106-P066)
- pAAV-EF1a-DIO-EGFP-WPRE (Cat#: NTA-2012AD-P285)
- Dextran, Cy5 Labeled, 2000 kDa (Cat#: NRZP-0722-ZP22)
- AAV2 Full Capsids, Reference Standards (Cat#: NTC2101070CR)
- VSV-eGFP (Cat#: NTA-2011-ZP20)
- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0832)
- Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged (Cat#: NEP-0621-R0041)
- ABCA1 Antisense Oligonucleotide (NV-2106-P27) (Cat#: NV-2106-P27)
- Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0497)
- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-SGSH BBB Shuttle Protein (Cat#: NRZP-0423-ZP505)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-NAGLU BBB Shuttle Protein (Cat#: NRZP-0423-ZP506)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP502)