Gene Therapy Tools

Creative Biolabs is a supplier of products designed for use in neuroscience research. We offer a variety of neuroscience research tools and services, covering areas such as basic research, neurological diseases, neural cell culture, and neural model construction. After extensive product development, we are pleased to announce the launch of several new tools for gene silencing and expression. Our products will assist you in achieving your research objectives, whether you are looking to knock out, knock in, knock down, or overexpress your target.

We are always expanding the product list. Please contact us and tell us your requirements and we'll customize the products according to your needs.

Product Overview

Advances in genome engineering, from the study of disease mechanisms to drug development, are enabling researchers to make unprecedented breakthroughs in neurological disorders. Our selection comprises, but is not restricted to:

• RNAi Substrates: We provide three types of small RNAs for RNAi: short hairpin RNA (shRNA), small interfering RNA (siRNA), and microRNA (miRNA). Creative Biolabs offers an extensive selection of products for many popular targets in neurological disorders, such as APOE, Tau, SOD1, CTNNB1, Huntingtin and others. We can also tailor RNAi solutions to match your specific requirements.
• Gene Expression Vectors: With our ready-to-use expression vectors, you can skip the time-consuming cloning, validation, and sequence analysis steps. We provide an array of expression systems, promoter clones, fusion tags and screening markers, and you can customize or purchase pre-made, ready-to-use expression vectors.
• Antisense Oligonucleotides (ASOs): We now have a list of ready-to-use ASO products for research into a number of neurological disorders. If you have identified a prospective RNA target and are looking for the best ASO, we can provide a customized solution.
• Viral Tracers: Viral products play a pivotal role in gene therapy, particularly as gene delivery vectors. By engineering viruses to remove their pathogenicity while preserving their delivery capabilities, viral vectors have become a cornerstone of gene therapy.
• MicroRNAs (miRNAs): As critical regulators in neurogenesis and synaptic plasticity, miRNAs are key targets for neurological research. We offer a complete suite of tools including mimics, inhibitors, and in vivo-ready agomirs/antagomirs to precisely manipulate miRNA activity and study their roles in diseases like Alzheimer's and Parkinson's.
• Circular RNAs (circRNAs): These exceptionally stable RNA molecules are highly enriched in the brain and are emerging as key players in synaptic function and neurodegeneration. We provide cutting-edge solutions, including custom synthesis and advanced LNP-encapsulated circRNAs, to explore their potential as novel biomarkers or therapeutic agents.
• Aptamers: Often termed 'chemical antibodies,' these oligonucleotides can be engineered to bind with high affinity to challenging neurological targets such as Tau aggregates and amyloid-beta plaques. We develop custom aptamers for use as robust diagnostic probes, imaging agents, or therapeutic inhibitors, offering a stable alternative to traditional antibodies.

Advantages

• Strict quality control and cost-effective.
• Available on request for flexible synthesis sizes and bulk orders.
• Cover several kinds of targets for neurological disorders.

Trending Products

Alzheimer's Disease

Parkinson's Disease

Amyotrophic Lateral Sclerosis

Huntington's Disease

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NoGeneST™ Anti-LRRK2 Aptamer, aLRRK2 aptamer [CAT#: NRYF-0625-HZ89]

Aptamer designed to specifically recognize Leucine-Rich Repeat Kinase 2, a key protein kinase implicated in Parkinson's disease.

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NoGeneST™ Gene Silencing siRNA Kit, Lrrk2 (Human/Mouse/Rat) [CAT#: NRYF-0625-XY429]

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.

Applications:

Gene Silencing

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NoGeneST™ LRRK2-ASO, Antisense Oligonucleotide [CAT#: NRYF-0625-XY73]

Applications:

Reduces LRRK2 expression to study its role in neuronal autophagy, mitochondrial dysfunction, and dopaminergic neurodegeneration in Parkinson's disease (PD). Enables preclinical evaluation of LRRK2 inhibition for neuroprotection. Optimized for in vivo PD models (e.g., α-synuclein transgenic mice).

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Mouse leucine rich repeat kinase 2 (Lrrk2) (NM_025730) clone/lentiviral particle, Untagged [CAT#: NEP-0621-R0032]

The clone can express a complete ORF with a certain tag. Different ways of expression depend on the specific nature of the gene.

Insert Size (bp):

7584 bp

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Rat leucine rich repeat kinase 2 (Lrrk2) (NM_001191789) clone/lentiviral particle, Untagged [CAT#: NEP-0621-R0031]

The clone can express a complete ORF with a certain tag. Different ways of expression depend on the specific nature of the gene.

Insert Size (bp):

7581 bp

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Lenti of Human leucine rich repeat kinase 2 (LRRK2) (NM_198578) ORF clone, Myc-DDK Tagged [CAT#: NEP-0621-R0030]

The clone can express a complete ORF with a certain tag. Different ways of expression depend on the specific nature of the gene.

Insert Size (bp):

7581 bp

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Human leucine rich repeat kinase 2 (LRRK2) (NM_198578) clone, Untagged [CAT#: NEP-0621-R0029]

The clone can express a complete ORF with a certain tag. Different ways of expression depend on the specific nature of the gene.

Insert Size (bp):

9300 bp

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Mouse leucine rich repeat kinase 2 (Lrrk2) (NM_025730) ORF clone/lentiviral particle, TurboGFP Tagged [CAT#: NEP-0621-R0028]

The clone can express a complete ORF with a certain tag. Different ways of expression depend on the specific nature of the gene.

Insert Size (bp):

7581 bp

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Rat leucine rich repeat kinase 2 (Lrrk2) (NM_001191789) ORF clone/lentiviral particle, Myc-DDK Tagged [CAT#: NEP-0621-R0027]

The clone can express a complete ORF with a certain tag. Different ways of expression depend on the specific nature of the gene.

Insert Size (bp):

7578 bp

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Human leucine rich repeat kinase 2 (LRRK2) (NM_198578) ORF clone/lentiviral particle, TurboGFP Tagged [CAT#: NEP-0621-R0026]

The clone can express a complete ORF with a certain tag. Different ways of expression depend on the specific nature of the gene.

Insert Size (bp):

7581 bp

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Mouse leucine rich repeat kinase 2 (Lrrk2) (NM_025730) ORF clone, Myc-DDK Tagged [CAT#: NEP-0621-R0025]

The clone can express a complete ORF with a certain tag. Different ways of expression depend on the specific nature of the gene.

Insert Size (bp):

7587 bp

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Human leucine rich repeat kinase 2 (LRRK2) (NM_198578) ORF clone/lentiviral particle, Myc-DDK Tagged [CAT#: NEP-0621-R0024]

The clone can express a complete ORF with a certain tag. Different ways of expression depend on the specific nature of the gene.

Insert Size (bp):

7581 bp

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Datasheet MSDS