Oligodendrocyte Marker Related Research Reagents

Oligodendrocytes (ODs) are glial cells in the central nervous system (CNS) that form the myelin sheath of axons to support rapid nerve conduction. OD also contributes to neuroplasticity and provides nutritional support for neurons. Each OD can interact with multiple axons and has the ability to quickly update its myelin sheath. Each myelin sheath of oligodendrocytes has up to 50 independent axons. As a result, OD has a high metabolic rate and is very susceptible to oxidative stress. OD is highly sensitive to pro-inflammatory molecules produced during inflammation and responds by producing low-quality myelin. In addition, OD can also affect neuronal survival, axon transport, axon caliber, and ion channel aggregation along the axon. OD damage and dysfunction are responsible for the development of many diseases and conditions, including multiple sclerosis, schizophrenia, and bipolar disorder.

Each stage of oligodendrocyte differentiation and maturation can be monitored by the specific morphology markers, including the most common maturation stage markers CNPase, Olig2 and oligodendrocyte marker O4. Creative Biolabs provides a series of research tools needed to study the development, maturation and function of oligodendrocytes. Our product portfolio includes monoclonal antibodies, polyclonal antibodies, labeled antibodies, proteins, analytical kits, and small molecule activators and inhibitors.

Summary of Oligodendrocyte Markers Provided by Creative Biolabs

Oligodendrocyte Precursor Cell Markers

Immature Oligodendrocyte Markers

Non-Myelinating Oligodendrocyte Markers

Myelinating Oligodendrocyte Markers

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NeuroMab™ Rabbit Anti-PMP22 Monoclonal Antibody (CBP7060) [CAT#: NAB-0720-Z9045]

PMP22 Rabbit Monoclonal Antibody

Host Species:

Rabbit

Species Reactivity:

Mouse; Rat; Human

Applications:

IMC™; WB; IHC-P; IHC-Fr

Conjugation:

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3407

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Datasheet MSDS

NeuroMab™ Rabbit Anti-PMP22 Monoclonal Antibody (CBP7050) [CAT#: NAB-0720-Z9024]

PMP22 Rabbit Monoclonal Antibody

Host Species:

Rabbit

Species Reactivity:

Human

Applications:

WB; IHC-P; ICC; IF; IP; FCM

Conjugation:

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 3400

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Datasheet MSDS

NeuroMab™ Rabbit Anti-Human PMP22 Monoclonal Antibody (CBP1644) [CAT#: NAB-08-PZ1029]

Rabbit Monoclonal Antibody to PMP22

Host Species:

Rabbit

Species Reactivity:

Human

Applications:

ICC; IF; FC; IHC-P; WB

Conjugation:

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1403

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Datasheet MSDS