TDP-43 Antibodies

TDP-43 (TAR DNA binding protein 43), expressed by the TARDBP gene, can bind both DNA and RNA and plays a critical role in intracellular RNA transcription, alternative splicing, and regulation of mRNA stability. Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) are both defined by lesions caused by aberrant TDP-43 aggregation. TDP-43 is the third protein associated with Alzheimer's disease (AD), and it plays a key role in AD progression. Apart from tau and amyloid-β (Aβ), most AD patients also have TDP-43 accumulation in the limbic regions. This accumulation has been dubbed the limbic predominance of age-related TDP-43 neuropathological changes in encephalopathy (LATE-NC).

The Impact of TDP-43 on AD Pathology

The specific mechanism of TDP-43 in AD is still not completely clear. TDP-43 can influence a wide range of physiological processes by forming complex core molecules and controlling gene transcription. However, in AD, TDP-43 frequently loses its normal function and forms toxic aggregates in neurons. This aberrant buildup of TDP-43 is thought to promote neuronal death, leading to clinical symptoms of AD such as memory loss and cognitive decline.

Furthermore, researchers have discovered a link between the TDP-43 protein and disease progression. AD patients with aberrant TDP-43 often proceed more quickly than patients with normal TDP-43. These individuals may acquire clinical signs early and experience rapid AD progression.

Fig.1 TDP-43 in Alzheimer's disease.¹

TDP-43 Antibodies Selection Guide

Creative Biolabs' TDP-43 antibodies have consistently shown good performance in scientific research trials due to their high specificity and sensitivity. Whether used for Western blotting, immunohistochemistry, or flow cytometry, it yields clear, consistent findings. Choose our TDP-43 antibodies to make your research more precise and effective. If you want to learn more about TDP-43 antibodies, please use the form below or contact us directly, and we will get back to you as soon as possible.

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References

1. Meneses, Axel, et al. "TDP-43 pathology in Alzheimer's disease." Molecular neurodegeneration 16 (2021): 1-15. Distributed under Open Access license CC BY 4.0, without modification.