Creative Biolabs

Celastrol from Celastrus scandens [Anti-inflammatory and antiproliferative agent]

[CAT#: MOD2005ZP923]

Anti-inflammatory and antiproliferative agent

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Description
Anti-inflammatory and anti-proliferative effects (IC50 = 2.12 µM). It can regulate a variety of cell signal transduction pathways (inhibit NF-κB, up-regulate cytoplasmic HSP70 and HSP27, inhibit VEGF/Akt/mTOR pathway and inhibit TNF-α, proteasome inhibitor).
Synonyms
Tripterine
Chemical Name
(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Research Areas
Neurodegenerative Diseases
Pathways
Alzheimer's Disease Signaling
Molecular Weight
450.60
Chemical Formula
C29H38O4
Source
Celastrus scandens
Solubility
Soluble in DMSO to 100 mM and in ethanol to 25 mM
CAS NO.
34157-83-0
PubChem Substance ID
122724
Purity
> 99%
Storage
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
Handling Advice
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Toxic, refer to SDS for further information.

Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
For Research Use Only. Not For Clinical Use.
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