Creative Biolabs

Chemically-modifiedβ-Amyloid Peptide, 1-42 aa

[CAT#: NPP2012026CR]

Unconjugated peptide for APPI

Sequence:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

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Description
It is well suited to the quantitative determination of A 42 peptide. Alzheimer's disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (A), a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase (BACE) and a putative (gamma) secretase. Increased release of the 'longer forms' of A peptide, A 42 and A 43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles or may other, still undiscovered factors.
Length
42AA
Sequence
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Amino Acids
ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL
HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL
GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL
GLY-GLY-VAL-VAL-ILE-ALA
Construction
1-42 aa
Molecule Mass
4514.1
Conjugation
Unconjugated
CAS NO.
107761-42-2
Molecular Formula
C203H311N55O60S1
Relevant Diseases
Neurological Disorders; Alzheimer's Disease; Prion Disease
Application Notes
T-cell assays; Immune monitoring; Antigen specific T-cell stimulation; T-cell expansion; Cellular immune response
Research Areas
Neuropeptide
Form
Powder
Quality
The contents of this vial have been accurately determined.
Purity
>95%, as determined by SDS-PAGE
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store in freezer(-20°C). Store away from oxidizing agents. Protect from heat. Keep container tightly sealed.
Handling Advice
Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
APPI
Official Name
APPI
Full Name
Beta-amyloid
Alternative Names
APP; AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; amyloid beta precursor protein; preA4; Amyloid peptide; amyloid beta protein; beta amyloid plaques
Gene ID
351(Human); 11820(Mouse)
Uniprot ID
P05067(Human); P12023(Mouse)
For Research Use Only. Not For Clinical Use.
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