Creative Biolabs

CHIR 99021 trihydrochloride [GSK3 Inhibitor]

[CAT#: MOD2005ZP507]

A highly potent, selective GSK3 inhibitor. Wnt signaling activator. Water soluble.

Target:
GSK-3

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Description
A highly effective, selective and competitive ATP competitive GSK3β inhibitor (IC50 values ​​of GSK-3β and GSK-3α are 6.7 and 10 nM, respectively).
Water soluble hydrochloride of CHIR 99021
Wnt signal activator, commonly used with PD 032501 as part of the 2i condition.
No cross-reactivity to CDK, selectivity to GSK3 is>500 times higher than other protein kinases, and selectivity to more than 20 other enzymes and receptors>800 times.
Promote the self-renewal of embryonic stem cells and reprogram mouse embryonic fibroblasts (MEF) to iPSC.
Chemical Name
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethy l]amino]-3-pyridinecarbonitrile trihydrochloride
Modulator Type
Inhibitor
Relevant Disease
Neurological Disorders
Molecular Weight
955.24
Chemical Formula
C22H18Cl2N8.3HCl
SMILES
CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl.Cl.Cl
Solubility
Soluble in water (25mM) and in DMSO (50mM)
CAS NO.
1782235-14-6
PubChem Substance ID
78243722
Purity
>98%
Storage
-20°C
Shipping
Room Temperature
Research Use Only
For research use only
Target
GSK-3
Official Name
GSK-3
Full Name
Glycogen synthase kinase 3
Alternative Names
Glycogen Synthase Kinase 3; GSK3; Glycogen Synthase Kinase-3
Gene ID
2932(Human); 56637(Mouse); 84027(Rat)
Uniprot ID
P49841(Human); Q9WV60(Mouse); P18266(Rat)
For Research Use Only. Not For Clinical Use.
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