Domperidone [Dopamine D2 Receptor Antagonist]
[CAT#: MOD2005ZP222]
Peripheral dopamine D2-like receptor antagonist
- Target:
- DRD2
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Description
Domperidone is a dopamine blocker and anti-dopaminergic drug. Target: Dopamine receptors. Due to better tolerability, domperidone is a useful alternative to metoclopramide for the treatment of gastroparesis. Domperidone is a dopamine D(2) receptor antagonist that has been used as an antiemetic in humans. Domperidone is a dopamine antagonist that does not easily cross the blood-brain barrier and is considered the gold standard for the treatment of gastrointestinal symptoms in patients with Parkinson's disease (PD).
Synonyms
R 33812
Chemical Name
5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo -1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-d ihydro-2H-benzimidazol-2-one
Modulator Type
Antagonist
Relevant Disease
Parkinson's Disease
Molecular Weight
425.92
Chemical Formula
C22H24ClN5O2
SMILES
ClC1=CC=C2N(C3CCN(CCCN4C(=O)NC5=C4C=CC=C5)CC3)C(=O)NC2=C1
Solubility
Soluble in DMSO (100mM) or water (5mM, 1eq. HCl)
CAS NO.
57808-66-9
PubChem Substance ID
3151
Purity
>98%
Storage
Room temperature
Shipping
Room Temperature
Research Use Only
For research use only
Neural Proteins & Peptides
Modulators
Neural Antibodies
Neural Cell Lines
Biomaterials
For Research Use Only. Not For Clinical Use.
