Dorsomorphin dihydrochloride [AMPK; ALK2; ALK3; ALK6 Inhibitor]
A highly potent, selective AMPK inhibitor. Also promotes cardiomyocyte differentiation in mouse embroynic stem cells (mESCs).
Dorsomorphin (Compound C: 0.2 mg/kg, intravenously 30 minutes before LPS injection) can reduce the expression of ICAM-1 and VCAM-1 in the aorta of LPS-injected rats .
Compared with animals stimulated with LPS only, treatment with Dorsomorphin (Compound C; 25 mg/kg; i.p. injection, in male BALB/c mice) before lipopolysaccharide (LPS) injection significantly reduced the lethality.
. Kim YM, et al. Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo. Atherosclerosis. 2011 Nov;219(1):57-64.