E-64 [cysteine protease Inhibitor]
[CAT#: MOD2005ZP924]
Irreversible, selective, potent cysteine protease inhibitor
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Description
Irreversible, effective and selective cysteine protease inhibitors (in vitro IC50 values of cathepsin K, S and L are 1.4, 4.1 and 2.5 nM, respectively). Does not inhibit serine proteases (except trypsin).
Synonyms
1-trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane; L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagmatine; N-(trans-Epoxysuccinyl)-L-leucine 4-guanidinobutylamide; trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane
Chemical Name
(2R,3R)-3-[[(2S)-1-[4-(Diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid
Modulator Type
Inhibitor
Research Areas
Neurodegenerative Diseases
Pathways
Alzheimer's Disease Signaling
Molecular Weight
357.41
Chemical Formula
C15H27N5O5
Source
Synthetic
SMILES
CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O
Solubility
Soluble in water to 50 mM and in DMSO to 50 mM
CAS NO.
66701-25-5
PubChem Substance ID
439487
Purity
> 99%
Storage
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling Advice
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
For Research Use Only. Not For Clinical Use.
