iPSC-derived Astrocyte Generation Service
Astrocytes are a major type of glial cell in the central nervous system (CNS). They play vital roles in providing structural and metabolic support to neurons, regulating neurotransmission, modulating synaptic connectivity, and maintaining the blood-brain barrier. Astrocyte dysfunction has been implicated in many neurodegenerative diseases and neurological disorders.
Astrocytes can be derived from human induced pluripotent stem cells (iPSCs) through specific differentiation protocols. iPSCs are stem cells reprogrammed from somatic cells like skin or blood cells back into a pluripotent state. The iPSCs can then be directed to become astrocyte progenitor cells that mature into functional astrocyte-like cells.
Key Advantages of iPSC-derived Astrocytes
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Applications of iPSC-derived Astrocytes in Research
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Common Assays Utilize iPSC-derived Astrocytes
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Astrocyte Dysfunction is Implicated in
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Reference
- Sonninen, Tuuli-Maria et al. "Metabolic alterations in Parkinson's disease astrocytes." Sci Rep. 2020;10(1):14474. Distributed under Open Access license CC BY 4.0. The original image was modified.
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