Creative Biolabs

Human GRM1 Calcium Assay [U2OS]

[CAT#: NRZP-0922-ZP1343]

Target:
GRM1
Species:
Human
Cell Types:
Calcium Assay Cell; Ion Channel Cell

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Description
Native calcium GPCR detection provides a fast and reliable method for detecting changes in intracellular calcium. Cells expressing target receptors that signal through calcium are preloaded with calcium-sensitive dyes and then treated with compounds. When stimulated, the receptor signals the release of intracellular calcium, which leads to an increase in dye fluorescence. This assay provides a homogeneous assay format for detecting calcium mobilization and measuring intracellular calcium, providing valuable information about GPCR and ion channel activation status. The signal is measured on a fluorescence plate reader equipped with a fluid handling device, which can detect rapid changes in fluorescence during complex stimuli. These assays are designed to be compatible with 96-well and 384-well plate formats.
Creative Biolabs offers custom functional assay services. We also offers this assay as a "stable cell line" in a cryopreserved vial. Please feel free to contact us for more details.
Assay Type
Calcium Flux Assay
Assay Characteristics

Tag: None
Agonist/Ligand: L-Glutamate
Receptor Family
; Metabotropic glutamate;
Cell Models Used
Human GRM1 Calcium Cell Line [U2OS]
Cell Models ID
NCL-7P777
Cell Model Features
The calcium cell line overexpresses natural Gq-coupled wild-type GPCRs and is designed to detect calcium mobilization in response to receptor agonist stimulation. You can use the Calcium No WashPLUS detection kit to detect the signal.
Cell Types
Calcium Assay Cell; Ion Channel Cell
Species
Human
Shipping
Dry ice.
Storage
Liquid Nitrogen
Research Use Only
For research use only
Quality Control
All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Target
GRM1
Alternative Names
GPRC1A; GRM1A; MGLUR1; MGLUR1A; glutamate receptor; metabotropic 1; mGlu1; metabotropic glutamate receptor 1
For Research Use Only. Not For Clinical Use.
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