Product
Human HEK293/TP Stable Cell Line
[CAT#: NCL20120120CR]
TP Prostanoid Receptor Stable Cell Line
- Species:
- Human
- Applications:
- GPCR Screening
- Cell Types:
- HEK293; GPCR Cell
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Overview
Description
It is a member of the G protein-coupled receptor (GPCR) superfamily which mediates TxA2-induced platelet aggregation and vasoconstriction. Dysregulation of TxA2 synthesis and function has been implicated in the pathogenesis of a number of disease states including myocardial ischemia, asthma, pregnancy-induced hypertension, and a variety of kidney diseases. TP receptors (Thromboxane A2 receptors) are widely distributed among different organ systems and localized on both cell membranes and in intracellular structures. Two isoforms of human TPs have been cloned from placenta (TPα) and endothelium (TPβ) that differ in their mechanisms and kinetics of desensitization and internalization.
Cell Types
HEK293; GPCR Cell
Applications
GPCR Screening
Research Areas
GPCR
Species
Human
Properties
Size
>1x10^6 Cells
Form
Frozen cells
Culture Medium
DMEM, 10% FBS, 300 μg/ml G418
Freeze Medium
45% culture medium, 45% FBS, 10% DMSO
Receptor
TP/TBXA2R
Family
Prostanoid receptor
Strain
TP Cell Line
Cell Purity
>95%
Shipping
Dry ice
Storage
Liquid nitrogen immediately upon delivery
Handling Advice
Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
repeated exposure.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Warnings
Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.
Target Details
Target
TP
Official Name
TP
Alternative Names
TP receptor; thromboxane; thromboxane A2 / prostaglandin H2; TXA2; TXA2-R; TXR2; Thromboxane receptor; prostanoid TP receptor; thromboxane A2 receptor; Tp receptor; TP
References
1. Hamidi, S. R., Safdari, Y., & Arabi, M. S. (2019). Test bacterial inclusion body for activity prior to start denaturing and refolding processes to obtain active eukaryotic proteins. Protein expression and purification, 154, 147-151. 2. Banisadr, A., Safdari, Y., Kianmehr, A., & Pourafshar, M. (2018). Production of a germline-humanized cetuximab scFv and evaluation of its activity in recognizing EGFR-overexpressing cancer cells. Human vaccines & immunotherapeutics, 14(4), 856-863. 3. Pourafshar, M., Safdari, Y., Khajeniazi, S., Yazdani, Y., Banisadr, A., & Veisi, K. (2018). Production and Characterization of Single Chain Nimotuzumab: An In Vitro Study. International Journal of Peptide Research and Therapeutics, 24(1), 171-178.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
