Huntington's Disease (HD) Animal Model Development Services

Huntington's Disease (HD) is a progressive neurodegenerative disorder caused by an expansion of CAG repeats in the Huntingtin (HTT) gene. This mutation leads to the production of a toxic mutant Huntingtin protein, resulting in neuronal dysfunction and a range of motor, cognitive, and psychiatric symptoms. Animal models are crucial tools for understanding HD pathogenesis and developing effective therapies. Our HD animal model development service helps you accelerate your research and obtain translatable results through advanced CRISPR-based genome editing and a comprehensive suite of in vivo study capabilities.

How Our HD Animal Models Can Assist Your Project?

Our HD animal model development service provides you with customized, in vivo models designed to meet your specific research needs. We deliver reliable tools to accelerate your research.

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Workflow:

Our workflow is designed to provide a streamlined and efficient process for generating and utilizing HD animal models.

• Required Starting Materials:
  • Target gene sequence information (HTT gene).
  • Specific desired mutation (CAG repeat expansion length).
  • Research objectives and study design.

• Final Deliverables:
  • Detailed study reports, including comprehensive data on model characterization, study design, experimental procedures, and statistical analyses.
  • Genetically defined and phenotypically characterized HD animal models.
  • Raw data and analyzed results, including behavioral data, imaging data, biochemical measurements, and histological images.
• Estimated Timeframe: The typical timeframe for this service ranges from 6 to 12 months, depending on the complexity of the model generation, the specific genetic modification required, and the scope of the in vivo studies.

Why Choose Us?

Creative Biolabs is a trusted partner in preclinical research, with over 20 years of experience in developing and characterizing complex animal models. We are dedicated to providing the highest quality HD models and services to accelerate your drug discovery efforts.

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Types of our HD Animal Models

CBL offers a variety of Huntington's Disease animal models, including:

• Transgenic models: These models express a mutant fragment of the human HTT gene.
• Knock-in models: These models have the expanded CAG repeat inserted into the endogenous mouse Htt gene, more closely mimicking the human genetic condition.
• Conditional models: These models allow for the expression of the mutant HTT gene to be controlled in a tissue-specific or time-dependent manner, providing greater flexibility for studying disease mechanisms.
• Humanized models: These models have the mouse Htt gene replaced with the human HTT gene.

Customer Reviews

"[Enhanced Translational Relevance] Using CBL's HD animal models in our research has significantly improved the translational relevance of our preclinical studies, allowing us to confidently progress to clinical trials." [6 Months], [J**n D**e]

"[Improved Data Quality] The detailed characterization and validation data provided with CBL's HD models have significantly facilitated the interpretation of our results and increased the rigor of our publications." [1 Year], [M**k S**h]

"[Accelerated Drug Discovery] CBL's expertise in CRISPR-based model generation has accelerated our drug discovery pipeline, enabling us to test novel therapeutic strategies more efficiently." [9 Months], [A**a R**z]

What We Can Offer

CBL offers a comprehensive suite of services to support your Huntington's Disease research, including:

• One-stop service: From initial consultation and design to final data analysis and reporting.
• Efficient process development: Streamlined upstream and downstream processes to accelerate model generation.
• Large-scale capacity: Access to our extensive vivarium facilities to support studies of any size.
• Quality assurance: A well-established quality system incorporating Quality-by-Design (QbD) and process analytical techniques (PAT).
• Stringent aseptic procedures: Meticulous aseptic verification procedures throughout the animal model generation process.
• GMP-compliant production: HD animal models generated under GMP-certified conditions.
• Customization: We optimize codon usage, control strain stability, and adjust culture conditions to maximize the yield and phenotype of your desired HD model.
• Quality control: High-standard quality control tools are employed to quantify and evaluate the quality of the HD models.
• Documentation and traceability: Documentation quality and strain origin are assessed and approved by our quality assurance service.

Related Services

CBL offers a comprehensive portfolio of neuroscience research services to support your drug discovery efforts:

• Custom Antibody Development: Generate highly specific antibodies for your HD-related targets.
• In Vitro Assay Development: Develop cell-based assays to screen potential HD therapeutics.
• Histopathology Services: Detailed analysis of brain tissue from HD animal models.

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