Creative Biolabs

IL-10 Protein, Human(CHO-expressed)

[CAT#: NPP-2011-ZP80]

Species:
Human

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Description
Interleukin-10 (IL-10), initially known as Cytokine Synthesis Inhibitory Factor (CSIF), belongs to the IL-10 family and shares more than 80% sequence homology with Epstein-Barr Virus protein BCRFI. It is produced by many immune cells, such as T-cells, macrophages, mast cells, and dendritic cells. It is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and Th2 cells. It also displays ability to suppress Antigen-Presenting Cell (APC) function. The net effect of Interleukin-10 appears to be inhibitory; however, stimulatory effects, such as stimulation of B cell maturation and antibody production, are also reported.
Species
Human
Biological Activity
ED50 < 0.2 ng/ml, measured in a cell proliferation assay using MC/9 cells.
Expression Host
CHO
Amino Acids
SPGQGTQSEN SCTHFPGNLP NMLRDLRDAF SRVKTFFQMKDQLDNLLLKE SLLEDFKGYL GCQALSEMIQ FYLEEVMPQAENQDPDIKAH VNSLGENLKT LRLRLRRCHR FLPCENKSKAVEQVKNAFNK LQEKGIYKAM SEFDIFINYI EAYMTMKIRN
Accession Number
P22301
Molecule Mass
18-19 kDa, observed by reducing SDS-PAGE.
Formulation
Lyophilized after extensive dialysis against PBS.
Purity
> 95% as analyzed by SDS-PAGE and HPLC.
Endotoxin Level
< 0.2 EU/μg, determined by LAL method.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Lyophilized recombinant Human Interleukin-10 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human Interleukin-10 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Handling Advice
Reconstituted in ddH2O or PBS at 100 μg/ml.
Research Use Only
This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Target
IL-10
For Research Use Only. Not For Clinical Use.
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