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iNeu™ Glutamatergic Neurons PRKN R275W/R275W, ALS Model
[CAT#: NRZP-0323-ZP14]
Human iPSC-derived Parkinson's Disease model
- Species:
- Human
- Cell Types:
- Glutamatergic Neurons
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Overview
Description
iNeu™ Glutamatergic Neurons PRKN R275W/R275W are precisely reprogrammed glutamatergic neurons carrying a genetically engineered homozygous mutation in the PRKN gene encoding parkin protein. These cells provide a rapidly maturing, disease-relevant isogenic system for studying the molecular and cellular significance of the homozygous R275W mutation in Parkinson's disease. Related disease model cells with homozygous PRKN R275W mutations are also available, and both can be used with their genetically matched control glutamatergic neurons.
Features
Making real comparisons
Pair disease model cells with genetically matched wild-type glutamatergic neurons to directly study the effects of heterozygous expression of mutant Parkin proteins on disease.
Scalable
Available in industrial-scale quantities, with industry-leading seeding densities, and at an affordable price, cells can be used from research to high-throughput screening.
Fast
Disease model cells and isogenic controls were ready for experiments as early as 2 days after resuscitation and formed structural neuronal networks by 11 days.
Pair disease model cells with genetically matched wild-type glutamatergic neurons to directly study the effects of heterozygous expression of mutant Parkin proteins on disease.
Scalable
Available in industrial-scale quantities, with industry-leading seeding densities, and at an affordable price, cells can be used from research to high-throughput screening.
Fast
Disease model cells and isogenic controls were ready for experiments as early as 2 days after resuscitation and formed structural neuronal networks by 11 days.
Neurological Disease Models
ALS-related Cells
Cell Types
Glutamatergic Neurons
Application Notes
Parkinson's disease research
Drug discovery and development
Disease modelling
Drug discovery and development
Disease modelling
Mutation Description
Homozygous R275W missense mutation in the PRKN gene
Relevant Diseases
Parkinson's and Gaucher disease
Species
Human
Properties
Size
>1 x 10^6 viable cells
Form
Frozen
Cell State
Cryopreserved cells
Growth Pattern
Adherent
Seeding Density
6, 12, 24, 48, 96 & 384 well plates
Tissue Source
Skin fibroblast
Shipping
Dry ice
Storage
LN2 or -150°C
Quality Control
Sterility, protein expression (ICC), gene expression (RT-qPCR) and genotype validation
Donor Information
Gender
Male
Donor Age
Adult
Ethnicity
Caucasian
Additional Donor Information
Normal (46, XY)
Publications
Publications (0)
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
