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Creative Biolabs
Product

iNeu™ Glutamatergic Neurons PRKN R275W/R275W, ALS Model

[CAT#: NRZP-0323-ZP14]

Human iPSC-derived Parkinson's Disease model

Species:
Human
Cell Types:
Glutamatergic Neuron

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Product Overview

Description

iNeu™ Glutamatergic Neurons PRKN R275W/R275W are precisely reprogrammed glutamatergic neurons carrying a genetically engineered homozygous mutation in the PRKN gene encoding parkin protein. These cells provide a rapidly maturing, disease-relevant isogenic system for studying the molecular and cellular significance of the homozygous R275W mutation in Parkinson's disease. Related disease model cells with homozygous PRKN R275W mutations are also available, and both can be used with their genetically matched control glutamatergic neurons.

Features

Making real comparisons
Pair disease model cells with genetically matched wild-type glutamatergic neurons to directly study the effects of heterozygous expression of mutant Parkin proteins on disease.

Scalable
Available in industrial-scale quantities, with industry-leading seeding densities, and at an affordable price, cells can be used from research to high-throughput screening.

Fast
Disease model cells and isogenic controls were ready for experiments as early as 2 days after resuscitation and formed structural neuronal networks by 11 days.

Cell Types

Glutamatergic Neuron

Application Notes

Parkinson's disease research
Drug discovery and development
Disease modelling

Mutation Description

Homozygous R275W missense mutation in the PRKN gene

Relevant Diseases

Parkinson's and Gaucher disease

Species

Human
Properties

Size

>1 x 10^6 viable cells

Form

Frozen

Cell State

Cryopreserved cells

Growth Pattern

Adherent

Seeding Density

6, 12, 24, 48, 96 & 384 well plates

Tissue Source

Skin fibroblast

Shipping

Dry ice

Storage

LN2 or -150°C

Quality Control

Sterility, protein expression (ICC), gene expression (RT-qPCR) and genotype validation
Donor Information

Gender

Male

Donor Age

Adult

Ethnicity

Caucasian

Additional Donor Information

Normal (46, XY)
Publications

Publications (0)

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Related Products
For Research Use Only. Not For Clinical Use.
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