Creative Biolabs

iNeu Microglia Kit

[CAT#: NCL-7P019]

Microglia differentiated from Human iPS cells, frozen

Species:
Human
Applications:
Cell Assay
Cell Types:
Microglia

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Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Description
Microglia are immune cells that reside in the central nervous system (CNS) and are responsible for basic physiological and pathological processes. Microglia support neuronal homeostasis and promote the formation of neuronal networks through synaptic pruning. Surveillance Microglia can activate, adapt and respond to specific stimuli accordingly. Microglia dysfunction is related to neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease, as well as neurodevelopmental disorders, such as Latter's synthesis Signs. The limited availability and inconsistency of primary Human microglia limit research and treatment progress.

iNeu Microglia overcomes the limitations of primary microglia by providing consistent, high-quality microglia derived from Human induced pluripotent stem cells, enabling the study of cytokine signaling, synaptic transmission, and normal CNS functions and Plasticity during disease progression.
Features
Human Relevance
iNeu Microglia exhibit functional characteristics similar to Human microglia, including phagocytosis and cytokine-mediated inflammatory responses, and express relevant microglial markers (TREM2, CX3CR1, TMEM119, P2RY12, IBA1).

Reproducible Research
Rigorous quality control and large-scale manufacturing capabilities ensure consistent performance and reproducible results from every lot of iNeu Microglia.

Rapid Results
iNeu Microglia are shipped cryopreserved and arrive fully differentiated allowing more experiments to be completed in less time.

Disease Models Available
Engineered disease model lines of iNeu Microglia are available for SNCA (A53T), TREM2, and MECP2.
Cell Types
Microglia
Applications
Cell Assay
Species
Human
Size
1 Vial: ≥ 1 x 10^6 cells/vial
Components
Cryopreserved iNeu Microglia, 01279
50ml iNeu Glial Base Medium
0.5ml iNeu Microglia Supplement A (100x)
0.5ml iNeu Microglia Supplement B (100x)
2 x 1ml iNeu Neural Supplement C (25X)
iNeu Microglia Quick Guide
Additional reagents required; see Quick Guide
Tissue Source
Blood
Age
50-59
Mycoplasma Testing
The cell line has been screened using the Mycoplasma Detection Kit to confirm the absence of Mycoplasma contamination.
Shipping
Dry ice.
Storage
Liquid Nitrogen
Research Use Only
For research use only
Quality Control
All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Target
ADRA2B
Official Name
ADRA2B
Alternative Names
Alpha-2B adrenoceptor; Adrenergic alpha2B- receptor class III; adrenergic receptor; alpha-2B adrenergic receptor; alpha-2B adrenoceptor; alpha-2BAR; alpha2B; [a]2B; Adra-2b
Gender
Male
Donor Health
Healthy
Ethnicity
Caucasian

For Research Use Only. Not For Clinical Use.
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