iNeuMab™ Anti-ANO3/TMEM16C BBB Shuttle Antibody (NRZP-0423-ZP24)
[CAT#: NRZP-0423-ZP24]
- Species Reactivity:
- Mouse; Rat
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ANO3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 163-257 (cytoplasmic N-terminus) of mouse ANO3 (also known as Anoctamin-3, Transmembrane protein 16C, Tmem16c, C11orf25 and GENX-3947, accession number A2AHL1)
Rat: 96% identity (91/95 amino acids identical)
Human: 88% identity (84/95 amino acids identical)
~50% identity with ANO4/TMEM16D
Rat: 96% identity (91/95 amino acids identical)
Human: 88% identity (84/95 amino acids identical)
~50% identity with ANO4/TMEM16D
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Mouse; Rat
Clonality
Monoclonal
Isotype
IgG2b
Research Areas
Ion channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
ANO3
Official Name
ANO3
Full Name
ANO3/TMEM16C
Alternative Names
ANO3
Uniprot ID
A2AHL1
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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