Name: iNeuMab™ Anti-Beta4-spectrin BBB Shuttle Antibody (NRZP-0423-ZP43)
SKU: NRZP-0423-ZP43
Rating: 5 (1 reviews)

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SPTBN4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin (also known as BetaIV-spectrin sigma1, Non-erythrocytic spectrin beta chain 4, Non-erythroid spectrin beta chain 3, SPTBN4, SPTBN3, Spnb4, KIAA1642, EMBL BAB83243.1 and Ensembl ENSRNOP00000028393, accession number Q9H254)
Mouse: 98% identity (209/212 aa identical)
Rat: 98% identity (209/212 aa identical)
>60% identity with Beta2-spectrin

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SPTBN4

Official Name

SPTBN4

Full Name

Beta4-spectrin

Alternative Names

BetaIV-spectrin sigma1 Antibody, Non-erythrocytic spectrin beta chain 4 Antibody, Non-erythroidspectrin beta chain 3 Antibody, SPTBN4 Antibody, SPTBN3 Antibody, Spnb4 Antibody, KIAA1642 Antibody, EMBL BAB83243.1 Antibody, Ensembl ENSRNOP00000028393 Antibody; Spectrin Beta, Non-Erythrocytic 4; Spectrin, Non-Erythroid Beta Chain 3; Beta-IV Spectrin; SPTBN3; Spectrin Beta Chain, Non-Erythrocytic 4; Spectrin Beta Chain, Brain 3