iNeuMab™ Anti-Tau Antibody (NRP-0422-P2295)
[CAT#: NRP-0422-P2295]
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- Inhib; Block; In Vitro; In Vivo
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SPECIFIC INQUIRY
inquiryProduct Overview
Description
This humanized, monoclonal IgG4 antibody binds to the central region of tau, recognizing amino acids 235-250 near tau's microtubule-binding domain. The rationale of this approach is that mid-region antibodies will more potently interfere with the cell-to-cell propagation of pathogenic, aggregated tau than do N-terminally targeted anti-tau antibodies. The antibody was reported to inhibit seeding in a cellular assay and inhibit spread of tau pathology in a mouse model. The antibody also binds tau monomers.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Humanized
Isotype
IgG
Applications
Inhib; Block; In Vitro; In Vivo
Relevant Diseases
Alzheimer's Disease
Product Properties
Formulation
PBS only
Preservatives
BSA Free
Concentration
1mg/mL
Purification
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Purity
>95% by SDS PAGE or HPLC
Endotoxin Level
Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg
Low Endotoxin < 1 EU/mg
Shipping
Gel Packs
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Research Use Only
For research use only
Target
Target
Tau
Official Name
MAPT
Alternative Names
MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40
Publications
Publications (0)
Neural Antibodies
Neural Genes
Kits
For Research Use Only. Not For Clinical Use.
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