iNeuMab™ Anti-Tau Antibody (NRP-0422-P2297)
[CAT#: NRP-0422-P2297]
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- Inhib; Block; In Vitro; In Vivo
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The humanized IgG1 monoclonal antibody binds to phosphorylated tau protein. It was generated by immunization of mice with a tau peptide spanning residues 386-408 and phosphorylated at serine 396 and 404. The mouse antibody, NRP-0422-P2297, preferentially bound hyperphosphorylated tau aggregates from brain, and reduced the ability of brain-derived tau to seed aggregation in cultured neurons and in rTg4510 tau transgenic mice. The antibody mediated uptake and lysosomal degradation of mouse-brain-derived pathological tau aggregates in primary microglia in culture; notably, this required effector function via the antibody's FcγReceptor.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Humanized
Isotype
IgG
Applications
Inhib; Block; In Vitro; In Vivo
Relevant Diseases
Alzheimer's Disease
Product Properties
Formulation
PBS only
Preservatives
BSA Free
Concentration
1mg/mL
Purification
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Purity
>95% by SDS PAGE or HPLC
Endotoxin Level
Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg
Low Endotoxin < 1 EU/mg
Shipping
Gel Packs
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Research Use Only
For research use only
Target
Target
Tau
Official Name
Tau
Alternative Names
MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40
Publications
Publications (0)
Neural Antibodies
Neural Genes
Kits
For Research Use Only. Not For Clinical Use.
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