Creative Biolabs

MLi-2 [LRRK2 Inhibitor]

[CAT#: MOD2005ZP765]

Potent and selective LRRK2 inhibitor

Target:
LRRK2

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Description
A potent and selective LRRK2 inhibitor. Inhibits LRRK2 in cell-free (IC50 = 0.76 nM), cell-based (IC50 = 1.4 nM) and radioligand binding (IC50 = 3.4 nM) assays. The selectivity to a set of receptors, channels and more than 300 kinases exceeds 295 times. Oral administration resulted in the decrease of Ser935 phosphorylation of LRRK2 in animal models.
Chemical Name
(2R,6S)-2,6-Dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholine
Modulator Type
Inhibitor
Research Areas
Neurodegenerative Diseases
Pathways
Parkinson's Disease Signaling
Molecular Weight
379.46
Chemical Formula
C21H25N5O2
Source
Synthetic
SMILES
C[C@@H]1CN(C[C@@H](O1)C)C2=NC=NC(=C2)C3=NNC4=C3C=C(C=C4)OC5(CC5)C
Solubility
Soluble in DMSO to 100 mM
CAS NO.
1627091-47-7
PubChem Substance ID
78319901
Purity
> 98%
Storage
Shipped at room temperature. Store at -20°C.
Handling Advice
Refer to SDS for further information.

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Target
LRRK2
Official Name
LRRK2
Full Name
Leucine-rich repeat kinase 2
Alternative Names
LRRK2; AURA17; DARDARIN; PARK8; RIPK7; ROCO2; leucine-rich repeat kinase 2; leucine rich repeat kinase 2
Gene ID
120892(Human); 66725(Mouse); 300160(Rat)
Uniprot ID
Q5S007(Human); Q5S006(Mouse)
Neural Antibodies
Neural Proteins & Peptides
Neural Vectors
Animal Models
Modulators
Kits
For Research Use Only. Not For Clinical Use.
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