Creative Biolabs

Mouse Anti-APOE Monoclonal Antibody (1B2C9), Unconjugated

[CAT#: NAB20101933CR]

Mouse Monoclonal (1B2C9) to APOE

Host Species:
Mouse
Species Reactivity:
Human; Mouse
Applications:
IHC; WB; ELISA

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Description
The apolipoprotein E (APOE) mediates the binding, internalization, and catabolism of lipoprotein particles, and also serve as a ligand for the LDL (APO B/E) receptor and for the specific APOE receptor (chylomicron remnant) of hepatic tissues. The very strong association of the APOE ɛ4 allele with AD risk and its role in the accumulation of amyloid β in brains of people and animal models solidify the biological relevance of APOE isoforms but do not provide mechanistic insight.
Expression Host
Mammalian cells
Immunogen
APOE fusion protein Ag28186
Species Reactivity
Human; Mouse
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
1B2C9
Applications
IHC; WB; ELISA
Application Notes
IHC : 1:20-1:200; WB : 1:500-1:1000
Relevant Diseases
Neurological Disorders
Research Areas
Growth and Development
Conjugation
Unconjugated
Form
Liquid
Formulation
PBS, 0.1% sodium azide and 50% glycerol pH 7.3.
Preservatives
Yes
Concentration
1000 μg/ml
Purification
Antigen affinity purification
Purity
>95%, as determined by SDS-PAGE
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store at -20°C. Stable for one year after shipment.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Apo E
Official Name
APOE
Full Name
Apolipoprotein E
Alternative Names
AD2; Apo E; APOE; apolipoprotein E; LPG
Gene ID
7804(Human); 16975(Mouse); 362558(Rat)
Uniprot ID
Q14114(Human); Q924X6(Mouse)
1. Morishita, H., Zhao, Y. G., Tamura, N., Nishimura, T., Kanda, Y., Sakamaki, Y.,... & Mizushima, N. (2019). A critical role of VMP1 in lipoprotein secretion. Elife, 8, e48834.
Kits
Neural Genes
Neural Antibodies
Neural Proteins & Peptides
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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