Product
Mouse Anti-Human AKT1 Monoclonal Antibody (CBP3988)
[CAT#: NAB2012973LS]
Anti-AKT1 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
AKT (Protein Kinase B, PKB) is a serine/threonine kinase that plays a key role in regulating cell proliferation, survival and metabolism. AKT disorders can lead to diseases such as cancer, diabetes, and cardiovascular and neurological diseases. There are three isotypes of AKT-AKT1, 2 and 3 (also called PKBα, β and γ). AKT is activated by oncogenic mutations in growth factors and other extracellular stimuli, as well as key upstream regulatory proteins (including Ras, PI3-kinase subunits, and PTEN). More and more evidences show that AKT1, 2 and 3 play a unique role in the occurrence and development of breast cancer. AKT1 has a cardioprotective effect on the heart by supporting its physiological growth and function. When conducting postmortem brain studies on patients with schizophrenia in many countries, it was found that AKT1 levels in the frontal cortex were reduced.
Immunogen
Full length recombinant protein of human AKT1 expressed in HEK293T cells.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1, κ
Clone Number
CBP3988
Applications
WB
Application Notes
WB (0.5-2.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
1.0 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
AKT1
Official Name
AKT1
Full Name
AKT Serine/Threonine Kinase 1
Alternative Names
AKT Serine/Threonine Kinase 1; V-Akt Murine Thymoma Viral Oncogene Homolog 1; Protein Kinase B Alpha; Proto-Oncogene C-Akt; RAC-PK-Alpha; EC 2.7.11.1; PKB Alpha; PKB; RAC; V-Akt Murine Thymoma Viral Oncogene-Like Protein 1; RAC-Alpha Serine/Threonine-Protein Kinase;
Publications
Publications (0)
Neural Antibodies
Kits
For Research Use Only. Not For Clinical Use.
