Product
Mouse Anti-Human BACE1 Monoclonal Antibody (CBP3719)
[CAT#: NAB201269LS]
Anti-BACE1 Monoclonal Antibody [HRP]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
β-Secretase 1 (BACE1) is a new type of membrane-bound aspartyl protease that can cleave β-amyloid precursor protein (βAPP) to generate the N-terminus of the Aβ domain. The membrane-bound C-terminal fragment produced by β secretase cleavage is then cleaved by γ secretase, resulting in the production and secretion of Aβ. The amyloidogenic peptide Aβ is the main factor in the etiology of Alzheimer's disease.
Immunogen
Recombinant human BACE1 protein.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2b, κ
Clone Number
CBP3719
Applications
WB
Application Notes
WB (1.0-5.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Alexa Fluor 594; Alexa Fluor 488; Alexa Fluor 498; Alexa Fluor 647; Alexa Fluor 700; APC; APC/Cyanine 7; APC/Fire 750; Biotin; Brilliant Violet 421; Brilliant Violet 510; Brilliant Violet 570; Brilliant Violet 570; Brilliant Violet 605; Brilliant Violet 650; Brilliant Violet 711; Brilliant Violet 750; Brilliant Violet 785; FITC; HRP; PE; Pacific Blue; PE/Cyanine 5; PE/Cyanine 7; PerCP; Spark YG 570
Product Properties
Form
Liquid
Formulation
50% glycerol in aqueous buffered solutions with preservatives.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon receipt, the antibody solution should be stored undiluted at-20°C, and protected from prolonged exposure to light.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
BACE1
Official Name
BACE1
Full Name
Beta-Secretase 1
Alternative Names
Beta-Secretase 1; Membrane-Associated Aspartic Protease 2; Beta-Site APP Cleaving Enzyme 1; Beta-Site APP-Cleaving Enzyme; Aspartyl Protease 2; EC 3.4.23.46; Memapsin-2; Asp 2; BACE; ASP2;
References
1. Vassar R, et al. 2014. J. Neurochem. 130:4-28.
2. Kandalepas PC, Vassar R. 2014. Curr. Alzheimers Res. 11:441-9.
3. Kandalepas PC, Vassar R. 2012. J. Neurochem. 120(Suppl. 1):55-61.
4. Gruninger-Leitch F, et al. 2002. J. Biol. Chem. 277:4687-93.
5. Koelsch G. 2017. Molecules. 22(10): E1723.
2. Kandalepas PC, Vassar R. 2014. Curr. Alzheimers Res. 11:441-9.
3. Kandalepas PC, Vassar R. 2012. J. Neurochem. 120(Suppl. 1):55-61.
4. Gruninger-Leitch F, et al. 2002. J. Biol. Chem. 277:4687-93.
5. Koelsch G. 2017. Molecules. 22(10): E1723.
Publications
Publications (0)
Neural Genes
Neural Cell Lines
Kits
Neural Antibodies
For Research Use Only. Not For Clinical Use.
