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Creative Biolabs
Product

Mouse Anti-Human Parkin Monoclonal Antibody (CBP3710)

[CAT#: NAB201254LS]

Anti-Parkin Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB; IHC-P

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Product Overview

Description

Parkin (also known as PARK2, AR-JP, PRKN) is a protein encoded by the PARK2 gene in humans. It is a component of the E3 ubiquitin ligase complex that mediates the targeting of proteins for degradation. Mutations in the PARK2 gene cause a familial form of Parkinson's disease called autosomal recessive juvenile parkinsonism (AR-JP).

Immunogen

Recombinant full-length human Parkin protein

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP3710

Applications

WB; IHC-P

Application Notes

WB (2.0-10 µg/mL); IHC-P (10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated
Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

Parkin

Official Name

PRKN

Full Name

Parkin

Alternative Names

PRKN; parkin RBR E3 ubiquitin protein ligase; AR-JP; LPRS2; PDJ; PARK2

Gene ID

5071(Human); 50873(Mouse); 56816(Rat)

Uniprot ID

O60260(Human); Q9WVS6(Mouse); Q9JK66(Rat)
References

1. Tay SP, et al. 2010. J Biol Chem. 285:29231-8.
2. Pawlyk AC, et al. 2003. J Biol Chem. 278:48120-8
Publications

Publications (0)

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